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Medicine composition of glycyrrhizic acid or its salt, ginseng and astragalus root

A kind of composition, technology of glycyrrhizic acid, applied in the field of medicine

Inactive Publication Date: 2007-06-27
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the interaction of glycyrrhizic acid or its pharmaceutically acceptable salt, ginseng or its extract, and astragalus or its extract, compatible prescriptions, for the treatment of liver diseases, has not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0171] Example 1 Preparation of ginseng extract with polysaccharide as the main active ingredient, i.e. ginseng polysaccharide

[0172] Ginseng polysaccharide preparation process:

[0173] Take ginseng, chop it up, extract it with 75% ethanol, reflux for 4 hours, filter, dry the dregs, add water to decoct five times, combine the decoction liquid, add 0.3% activated carbon, stir for 30 minutes, stand overnight, filter , the filtrate was passed through a resin column, the effluent was collected, concentrated under reduced pressure, added ethanol to make the alcohol content reach 95%, refrigerated, filtered, the precipitate was washed with acetone, the acetone was drained, the precipitate was taken out and dried at 60-80°C, crushed have to.

[0174] Ginseng Polysaccharide Identification Experiment

[0175] (1) Take about 0.2g of this product, add 5ml of water to dissolve, add 5 drops of alkaline copper tartrate test solution, heat to produce a red precipitate, cool, filter, t...

Embodiment 2

[0184] Example 2 Preparation of ginseng extract with total saponins as the main active ingredient, i.e. total ginsenosides

[0185] Preparation process of total ginseng saponins:

[0186] Take the ginseng medicinal material, crush it into fine particles, and extract twice with ethanol under reflux, each time for 3 hours, add 10 times the amount of alcohol each time, combine the extracts, refrigerate, filter, recover the ethanol from the filtrate and concentrate it to a thick paste, add water to an appropriate amount ( Make each 1ml equivalent to 1g of the original medicinal material), stir well, refrigerate, filter, add the filtrate to the processed macroporous resin column, first elute with 2V ~ 3V column volume of water, discard the washing solution, and then Elute with 3 times column volume of 80% ethanol, collect the eluate, recover the ethanol, concentrate under reduced pressure to a thick paste with a relative density of 1.30-1.35, and dry it in vacuum to obtain the pr...

Embodiment 3

[0201] Example 3 Preparation of astragalus extract, i.e. astragalus polysaccharide, with polysaccharide as the main active ingredient

[0202] Astragalus polysaccharide preparation process:

[0203] Take Radix Astragali, add 7 times the amount of 70% ethanol to extract twice, each time for 2 hours, discard the extract, take the dregs and add water to extract twice, combine the extracts, concentrate until the ratio of extraction volume to raw medicinal materials is 1.05:1 , add ethanol to precipitate to make the alcohol content reach 70%, filter to obtain a precipitate, wash the precipitate with 70% ethanol, dissolve it with an appropriate amount of water, filter, pass the filtrate through a macroporous resin, elute with water, collect the washing liquid, and concentrate the washing liquid When the ratio of the volume of the medicinal solution to the medicinal material is 1:2.5, add ethanol to make the alcohol content reach 70%, and a precipitate is obtained. The precipitate ...

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PUM

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Abstract

The present invention belongs to the field of medicine technology, and is especially one medicine composition for treating hepatitis and its preparation process and use. The medicine composition consists of glycyrrhizic acid or its pharmaceutically acceptable salt 4-800 weight portions, ginseng 250-16000 weight portions, and astragalus root 5000- 80000 weight portions. It may consist of glycyrrhizic acid or its pharmaceutically acceptable salt, the extract of ginseng and the extract of astragalus root. It may be prepared into different forms. The medicine composition has the synergistic effect of the components, high stability, high effect and wide application.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition mainly made of glycyrrhizic acid or its pharmaceutically acceptable salt, ginseng or its extract, astragalus or its extract and a preparation method thereof, belonging to the technical field of medicine. 2. Background technology [0002] Hepatitis is a common and frequently-occurring disease. According to incomplete statistics, hepatitis patients and virus carriers account for 10% of the total population in my country. Among them, viral hepatitis is the main one, and viral hepatitis can be divided into: acute hepatitis, chronic hepatitis, severe hepatitis and biliary hepatitis. Chronic hepatitis can be divided into persistent hepatitis and active hepatitis. Hepatitis is a kind of infectious disease, because of its widespread prevalence, great harm, and high incidence rate, it is one of the difficult diseases recognized at home and abroad. Taking hepatitis B as an example, the cure rate is only 1...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61P1/16A61P31/14A61P31/20A61K31/704
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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