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Apparatus for determining cellular composition information in one or more tissue samples

a technology of cellular composition and tissue sample, which is applied in the field of apparatus for determining cellular composition information in one or more tissue samples, can solve the problems of time and tissue consumption, and the inability to obtain cytotoxic t cells, and the partial subtype cannot be derived from morphological information, so as to improve technology

Active Publication Date: 2021-06-29
KONINKLJIJKE PHILIPS NV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text describes an improved technology for detecting cellular composition in tissue samples. This technology helps to mitigate imaging errors and simplifies processing by reducing the need for de-convolution of image data. It also enables the spatial position of cell densities in one image to be compared correctly with the spatial cell densities in another image.

Problems solved by technology

However, the particular subtype, like cytotoxic T cells, cannot be derived from morphological information only.
This is however time and tissue consuming (as multiple sections are required for multiplexed analysis).

Method used

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  • Apparatus for determining cellular composition information in one or more tissue samples
  • Apparatus for determining cellular composition information in one or more tissue samples

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Embodiment Construction

[0061]FIG. 1 shows an example of an apparatus 10 for determining cellular composition information in one or more tissue sample microscopic images. The apparatus 10 comprises an input unit 20, and a processing unit 30. The input unit 20 is configured to provide the processing unit 30 with at least one 2D image of at least one tissue sample, via wired or wireless communication. First image data of the at least one 2D image relates to a non-specific staining of a tissue sample of the at least one tissue sample. Second image data of the at least one 2D image relates to specific staining of a tissue sample of the at least one tissue sample. Either, (a) the tissue sample that has undergone specific staining is the same as the tissue sample that has undergone non-specific staining, or (b) the tissue sample that has undergone specific staining is different to the tissue sample that has undergone non-specific staining. The processing unit 30 is configured to determine a non-specific cellular...

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Abstract

The present invention relates to an apparatus (10) for determining cellular composition in one or more tissue sample microscopic images. It is described to provide (210) first image data of at least one tissue sample. The first image data relates to a non-specific staining of a tissue sample of the at least one tissue sample. Second image data of the at least one tissue sample is provided (220). The second image data relates to specific staining of a tissue sample of the at least one tissue sample. Either (i) the tissue sample that has undergone specific staining is the same as the tissue sample that has undergone non-specific staining, or (ii) the tissue sample that has undergone specific staining is different to the tissue sample that has undergone non-specific staining. A non-specific cellular composition cell density map is determined (230) on the basis of the first image data. A specific cellular composition cell density map is determined (240) on the basis of the second image data. Information regarding cellular composition in the at least one tissue sample is determined (250) on the basis of the non-specific cell density map and the specific cell density map.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This patent application claims the priority benefit under 35 U.S.C. § 371 of international patent application no. PCT / EP2017 / 0777487, filed Oct. 26, 2017, which claims the benefit of European Patent Application No. 16195995.5, filed on Oct. 27, 2016, and European Patent Application No. 16197370.6, filed on Nov. 4, 2016, the contents of which are hereby incorporated by reference herein.FIELD OF THE INVENTION[0002]The present invention relates to an apparatus for determining cellular composition information in one or more tissue samples, to a system for determining cellular composition information in one or more tissue samples, and to a method for determining cellular composition information in one or more tissue samples, as well as to a computer program element and a computer readable medium.BACKGROUND OF THE INVENTION[0003]Characterization of the tumor micro-environment in particular the immune infiltrate (or cellular composition) is of g...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): G06K9/00G01N21/00G02B21/36G06T7/00
CPCG06K9/00127G01N21/00G02B21/365G06T7/0012G06T2207/10024G06T2207/10056G06T2207/30024G06V20/69
Inventor VAREKAMP, CHRISTIAANWIMBERGER-FRIEDL, REINHOLDHALTER, DAVID
Owner KONINKLJIJKE PHILIPS NV
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