Antiseptic packaged polyvinylpyrrolidone-cinnamic alcohol solid products and the like and method of preparing the same

Abstract

A method of rendering antiseptic a packaged solid admixed emulsion for treating bleeding cuts and the like containing, dispersed therein, a bactericidal component that is solid at room temperature, such as cinnamic alcohol, but melts or liquefies at blood temperature upon contacting the blood, comprising elevating the temperature of the packaged emulsion and / or contacting with moisture briefly to commence such liquefying to wet the exterior surface of the solid emulsion, and with concurrent release of bactericidal vapor within the package, and the resulting antiseptic solid emulsion products produced thereby.

Description

[0001] The present invention is directed to methods of and products for enabling the disinfecting or antiseptic protecting and substantially room temperature storing of normally dry bacterial-component-containing solid emulsions for pharmacological use with bleeding cuts, wounds, and abrasions and the like; being more particularly concerned with the rendering antiseptic during packaged or other storage of such dry solid emulsions of the type that start to melt, sublime or liquefy at somewhat higher than room temperature, (as of the order of the temperature of human or animal blood in living subjects--about 98-100.degree. F.), upon being contacted by moisture, such as complexes of polyvinylpyrrolidone admixed with cinnamic alcohol and tannic acid, as described in U.S. Pat. Nos. 3,525,340 and 3,777,016 of Joseph G Gilbert, and in U.S. Pat. No. 4,094,967 of the Allor Foundation, common assignee of the present invention[0002] In the first two of the above-referenced Gilbert patents, the...

AI Technical Summary

Benefits of technology

[0013] FIGS. 3A and 3B are zone of inhibition photographs further illustrating the sterilizing effects of the invention on samples A and B

[0014] Underlying the present invention, is the discovery that, by causing the commencement of melting (including some sublimation) or liquefying--these words being used substantially synonymously herein--at the exposed surface of the bactericidal-component-containing solid admixed emulsions of the above-described type with which the present invention is concerned, as by short and slight temperature rise to the melting temperature of said component, and upon introduced moisture contact, as by steam or otherwise, bactericidal liquid starts to be drawn from and released through the exposed surface, wetting the same, this liquefying wetting process also releasing some vapor phase bactericidal vapor adjacent such surface and within the interior of the package in which the solid emulsion product may be contained By terminating the heat / moisture and its surface liquefying and vapor release just after the commencement thereof, (as by rapidly removing or lowering the temperature and / or sealing against further moisture), and thus restoring the emulsion to its normal solid room-temperature dry state within the package, the exterior surface becomes totally re-solidified, but now with a self-generated antiseptic bactericidal coating on its exposed surface, and the interior of the package has been rendered antiseptic by the exposure to the antiseptic bactericidal vapor released therein during and as a result of the short-period melting transition from solid to liquid (wetting).

[0015] More specifically, the before-described solid emulsions of admixed polyvinylpyrrolidone--cinnamic acid--tannic acid (and / or iodine) have been successfully so rendered antiseptic both for containment in packages and without packages by this technique of the invention

[0016] While as shown in above-cited patents, the complex of the invention is effective against a wide range of microorganisms for purposes of hereinafter described tests, E. coli was selected for illustrative use because of its current tenacity and pervasive problems, though the effects herein have also been observed on other microorganisms, including as described in said patents

Problems solved by technology

In retrospect, however, this turned out to be too radical a concept for acceptance by the medical and health-care-providing community which had and has the ingrained concept of universal aseptic products and packaging whether really needed or not.

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