Agents and compositions and methods utilizing same useful in diagnosing and/or treating or preventing plaque forming

a technology of agent composition and plaque forming, which is applied in the direction of antibody mimetics/scaffolds, peptide/protein ingredients, fusion polypeptides, etc., can solve the problems of teaching not providing means with which to enable, and the physiochemical properties of abnormalities are abnormal, and the effect of increasing the number o
US20030077252A1Inactive Publication Date: 2003-04-24RAMOT UNIV AUTHORITY FOR APPLIED RES & INDAL DEVMENT
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
RAMOT UNIV AUTHORITY FOR APPLIED RES & INDAL DEVMENT
Publication Date
2003-04-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

A method of immunizing against plaque forming diseases using display technology is provided. The method utilize novel agents, or pharmaceutical compositions for vaccination against plaque forming diseases which rely upon presentation of an antigen or epitope on a display vehicle. The method further includes agents, or pharmaceutical compositions for vaccination against plaque forming diseases, which rely upon presentation of an antibody, or an active portion thereof, on a display vehicle. Whether antigens or antibodies are employed, disaggregation of plaques results from the immunization.
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Description

[0001] The present application is a continuation of U.S. application Ser. No. 09 / 629,971, filed Jul. 31, 2000, which is a continuation-in-part of U.S. application Ser. No. 09 / 473,653, filed Dec. 29, 1999, which is a continuation-in-part of U.S. provisional application 60 / 152,417, filed Sep. 3, 1999, the entire contents of each being incorporated herein by reference.FIELD AND BACKGROUND OF THE INVENTION

[0002] The present invention relates to agents and compositions and to methods of utilizing same for treating plaque-forming diseases. More particularly, the methods according to the present invention involve the use of (i) plaque derived antigens cloned and displayed on the surface of a display vehicle for in vivo elicitation of antibodies capable of preventing plaque formation and of disaggregating existing plaques; and (ii) antibodies raised against plaque derived antigens, at least an immunologic portion of which is cloned and displayed on a display vehicle, which immunologic porti...

Claims

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