Methods and compositions for inactivating viruses

Inactive Publication Date: 2004-03-11
NV ORGANON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

0005] The present invention relates to methods and processes of inactivating a viral contaminants in a biological source material or process intermediate. The process of the present invention involves contacting the biological source material (e.g., a host cell, cell supernatant, cell lysate, blood plasma, tissue homogenate, or other biological materials) containing a biomolecule (e.g., a recombinant or native protein, lipid, nucleic acid, or carbohydrate) of interest with a solution containing one or more alkylamine compounds. In a particular embodiment, the active ingredients are amphipathic, charged amines or amine oxides coupled to saturated hydrocarbon chains of

Problems solved by technology

Due to the very nature of the biological materials or their methods of production, biological materials may contain unwanted agents of viral origin that may be pathological

Method used

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Embodiment Construction

[0009] The present invention relates to a process for the facile and non-denaturative inactivation of viruses present or potentially present in biological source materials. The process includes contacting the source material with certain charge-modified hydrocarbons under appropriate solution conditions.

[0010] In a particular embodiment, solution conditions are adjusted by sedimentation of an insoluble source material, for example, recombinant-host cells producing a recombinant protein of interest, followed by re-suspension, or by solution exchange using filtration methods, by direct modification of the existing solution conditions, or by other means of solvent exchange. Source materials suspended or co-dissolved in the appropriate solution are then contacted with certain amphipathic molecules that cause the inactivation of biological agents. Agents that may be inactivated in this way include bacteria, yeast, fungi, mycoplasma, mammalian cells, other animal cells and lipid enveloped...

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Abstract

The present invention relates to methods and processes of inactivating viral contaminants in a biological source material (e.g. a host cell, cell supernatant, cell lysate, blood plasma, tissue homogenate, or other biological materials) with a solution containing one or more alkylamine compounds. In a particular embodiment, the active ingredients are amphipathic, charged amines or amine oxides coupled to saturated hydrocarbon chains of varying lengths.

Description

1. TECHNICAL FIELD OF THE INVENTION[0001] The present invention relates to methods and compositions for inactivating viruses present in samples / process streams of biological origin.2. BACKGROUND OF THE INVENTION[0002] It is desirable to use biological materials as sources for medicinal and industrial intermediates and products. Due to the very nature of the biological materials or their methods of production, biological materials may contain unwanted agents of viral origin that may be pathological or otherwise undesirable. The intended end-use of materials derived from biological sources may require a reduction in the biological activity of viral agents known to be present, or that are potentially present, in the source material or process additives.[0003] Reduction of viral activity in materials is commonly accomplished by a number of techniques including the use of heat, steam, pressure, chemical treatments and other methods. However, these techniques may irreversibly alter the pr...

Claims

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Application Information

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IPC IPC(8): C12N1/00A01N33/04A01N33/24A61K31/131A61K35/00A61L2/00A61M1/36
CPCA01N33/04A01N33/24A61K31/131A61K35/00Y10S514/908A61L2/0082A61L2/0088A61M1/3687A61L2/0005
Inventor SHEPARD, SCOT R.
Owner NV ORGANON
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