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Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof

a technology of human kinase and nucleic acid molecules, applied in the field of kinase proteins, can solve the problems of overlapping prestalk and prespore domains, severe loss of compartment boundary, and delayed developmen

Inactive Publication Date: 2005-02-03
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0020]FIG. 2 provides the predicted amino acid sequence of the kinase of the present invention. (SEQ ID NO:2) In addition structure and functional information such as pro

Problems solved by technology

Cells deficient in MEKKα, develop precociously and exhibit abnormal cell-type patterning with an increase in one of the prestalk compartments (pstO), a concomitant reduction in the prespore domain, and a loss of the sharp compartment boundaries, resulting in overlapping prestalk and prespore domains.
Overexpression of MEKKα, or MEKKα lacking the WD40 repeats results in very delayed development and a severe loss of compartment boundaries.

Method used

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  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof

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Embodiment Construction

[0022] General Description

[0023] The present invention is based on the sequencing of the human genome. During the sequencing and assembly of the human genome, analysis of the sequence information revealed previously unidentified fragments of the human genome that encode peptides that share structural and / or sequence homology to protein / peptide / domains identified and characterized within the art as being a kinase protein or part of a kinase protein and are related to the MEK kinase alpha subfamily. Utilizing these sequences, additional genomic sequences were assembled and transcript and / or cDNA sequences were isolated and characterized. Based on this analysis, the present invention provides amino acid sequences of human kinase peptides and proteins that are related to the MEK kinase alpha subfamily, nucleic acid sequences in the form of transcript sequences, cDNA sequences and / or genomic sequences that encode these kinase peptides and proteins, nucleic acid variation (allelic inform...

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Abstract

The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.

Description

FIELD OF THE INVENTION [0001] The present invention is in the field of kinase proteins that are related to the MEK kinase alpha subfamily, recombinant DNA molecules, and protein production. The present invention specifically provides novel peptides and proteins that effect protein phosphorylation and nucleic acid molecules encoding such peptide and protein molecules, all of which are useful in the development of human therapeutics and diagnostic compositions and methods. BACKGROUND OF THE INVENTION [0002] Protein Kinases [0003] Kinases regulate many different cell proliferation, differentiation, and signaling processes by adding phosphate groups to proteins. Uncontrolled signaling has been implicated in a variety of disease conditions including inflammation, cancer, arteriosclerosis, and psoriasis. Reversible protein phosphorylation is the main strategy for controlling activities of eukaryotic cells. It is estimated that more than 1000 of the 10,000 proteins active in a typical mamm...

Claims

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Application Information

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IPC IPC(8): C12N9/12
CPCC12N9/1205A01K2217/05
Inventor WEBSTER, MARIONWEI, MING-HUIYAN, CHUNHUADI FRANCESCO, VALENTINABEASLEY, ELLEN
Owner APPLERA