ErbB4 antagonists

a technology of erbb4 and antagonists, applied in the field of erbb4 antagonists, can solve the problems of stenosis including vascular stenosis and restenosis, and achieve the effect of reducing heregulin binding and high affinity
US20060093603A1Inactive Publication Date: 2006-05-04GENENTECH INC
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
GENENTECH INC
Publication Date
2006-05-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention concerns methods and means for controlling excessive proliferation and / or migration of smooth muscle cells, and in particular for treating stenosis, by using antagonists of a native ErbB4 receptor. The invention further concerns a method for the identification of ErbB4 agonists and antagonists capable of inhibiting or enhancing the proliferation or migration of smooth muscle cells.
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Description

[0001] This application claims priority under 35 U.S.C. § 119(e) of U.S. provisional application Ser. No. 60 / 229,679 filed on Sep. 1, 2000, and 60 / 265,516 filed on Jan. 31, 2001, the entire disclosures of which are hereby expressly incorporated by reference.BACKGROUND OF THE INVENTION

[0002] 1. Field of the Invention

[0003] The present invention concerns methods and means for controlling excessive proliferation and / or migration of smooth muscle cells, and in particular for treating stenosis, by using antagonists of a native ErbB4 receptor. The invention further concerns a method for the identification of ErbB4 agonists and antagonists capable of inhibiting or enhancing the proliferation or migration of smooth muscle cells.

[0004] 2. Description of the Related Art 1. ErbB Receptor Tyrosine Kinases

[0005] Transduction of signals that regulate cell growth and differentiation is regulated in part by phosphorylation of various cellular proteins. Protein tyrosine kinases are enzymes that...

Claims

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