Modular targeted liposomal delivery system

a liposome and module technology, applied in the field of targeted liposomes, can solve the problems of reducing the amount of bioactive agents available to the target site, reducing the ability of the liposome, and difficult to deliver intact bioactive agents to the target site. the effect of liposome ability
US20060172003A1Inactive Publication Date: 2006-08-03TRANSAVE
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
TRANSAVE
Publication Date
2006-08-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

A liposome including a fusogenic liposome, a linking moiety and a targeting moiety. The fusogenic liposome is a lipid bilayer encapsulating contents. The linking moiety is electrostatically bound to the lipid bilayer, and the targeting moiety is covalently bound to the linking moiety. The liposome may also include a stabilizing moiety interposed between the linking and targeting moieties, and covalently bound to both. Alternatively, the stabilizing and targeting moieties may be covalently bound to separate linking moieties, the linking moieties being electrostatically bound to the lipid bilayer.
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Description

FIELD OF THE INVENTION

[0001] The invention relates to a targeted liposome capable of efficient intracellular delivery of one or more bioactive agents, a pharmaceutical composition including the targeted liposome, and a method of delivering the contents of a liposome to an in vivo or in vitro target site such as a tumor cell, site of inflammation or infection. BACKGROUND OF THE INVENTION

[0002] Pharmaceutical usefulness of bioactive agents depends upon the ability to position therapeutically-effective quantities of intact agent at the target site in the patient. Delivering intact bioactive agents to target sites can be difficult: In vivo degradation of bioactive agents can occur, as well as absorption / retention of the agent by non-targeted systems. Even if pharmaceutically effective amounts of intact agent can be delivered to the vicinity of the target site, accessing the functional location of the site for the bioactive agent can be challenging, particularly if that location is int...

Claims

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