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Topical cosmetic compositions comprising alpha arbutin

a technology of alpha arbutin and cosmetic composition, which is applied in the field oftopical cosmetic compositions, can solve the problems of irritants to individuals, hydroquinone is easy to hydrolyze, and acts more slowly, so as to prolong the time to meet the customer, the effect of easy hydrolysis

Inactive Publication Date: 2006-08-24
E T BROWNE DRUG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0023] Alpha arbutin avoids the direct toxicity of hydroquinone and the indirect toxicity of beta arbutin which easily hydrolyses to hydroquinone. Alpha arbutin acts more slowly than hydroquinone, taking a slightly longer time to meet the customer's skin lightening objectives when used alone. This invention involves the use of alpha arbutin and bearberry extract in combination, This combination is synergistic in skin whitening effectiveness, as the bearberry extract serves to potentiate the alpha arbutin. Moreover, the alpha-glucosidic bond has a higher stability than the beta gluosidic bond, giving greater stability and greater effectiveness than beta arbutin.
[0024] This patent teaches that the use of polyolprepolymer-2 in an admi

Problems solved by technology

However, hydroquinone is an irritant to some individuals, particularly those with light skin types, and may be cytotoxic to melanocytes.
It is not legally marketed in Japan, the Union of South Africa and several other countries at present, and several other countries are considering denying legal marketing clearance because of concern about long term toxicity.

Method used

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Embodiment Construction

[0023] Alpha arbutin avoids the direct toxicity of hydroquinone and the indirect toxicity of beta arbutin which easily hydrolyses to hydroquinone. Alpha arbutin acts more slowly than hydroquinone, taking a slightly longer time to meet the customer's skin lightening objectives when used alone. This invention involves the use of alpha arbutin and bearberry extract in combination, This combination is synergistic in skin whitening effectiveness, as the bearberry extract serves to potentiate the alpha arbutin. Moreover, the alpha-glucosidic bond has a higher stability than the beta gluosidic bond, giving greater stability and greater effectiveness than beta arbutin.

Advanced Liposome Delivery System

[0024] This patent teaches that the use of polyolprepolymer-2 in an admixture with alpha arbutin / bearberry extract. This is in order to both extend the stability of the alpha arbutin to avoid possible deleterious effects due to oxidation related to the oxygen in the atmosphere as well as that...

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Abstract

This invention is a topical tyrosinase inhibiting combination using alpha arbutin and bearberry extract, in synergism, for the purpose of skin lightening. The active admixture is a dermatological serum comprised of alpha arbutin, octyl stearate and polyolprepolymer-2, introduced onto the human skin in liposome form for ultra-deep penetration.

Description

REFERENCES CITED [REFERENCED BY]U.S. Patent Documents [0001]6,695,260May, 2003Ley, et al.6,537,527March, 2002Kvalnes, et al6,492,326December, 2002Robinson, et al6,077,503June, 2000Dornoff, et al.5,980,904November, 1999Ley, et Al.5,932,608August, 1999Nguyen, et. Al.5,854,327October, 1998Neis, et al.5,747,006May, 1998Dornoff, et al.5,700,784December, 1997Shinujima, et al5,310,730April, 1987Tokugan, et al4,764,505March, 1985Tokugan, et al4,278,656December, 1992Leverett et al.Foreign Patent Documents [0002]672746September, 1995EP.95 / 01157January, 1995WO.2577805January, 1994FROther References [0003] Abstracts of Japan, Vol. 11, No. 297 (C448)(2744) Sep. 25, (JPA 620 896081, Apr. 24, 1987. [0004] Centerchem Brochure: Alpha Arbutin, Norwalk, Conn. 2001. [0005] Cosmetics & Toiletries, vol. 111, pp.43-51, Giuseppe Prota, PhD, Melatanins and Melanogenesis, 1996 [0006] Gattefosse Brochure: “Gatulene Whitening,” BP603-F 69804 St. Priest Cedex, France. [0007] Laboratoire Serobiologiques brochure...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61K9/127A61K31/7034A61K36/45
CPCA61K8/14A61K8/602A61K8/97A61K31/7034A61K36/45A61K2800/782A61Q19/02A61K2300/00A61K8/9789
Inventor NEIS, ARNOLDNEIS, ROBERTWHITTEMORE, JERRY
Owner E T BROWNE DRUG
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