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Oral sustained-release preparation of fasudil hydrochloride

a technology of fasudil hydrochloride and oral suspension, which is applied in the direction of microcapsules, cardiovascular disorders, drug compositions, etc., can solve the problems of patient forgetting to take the preparation, low compliance, and low compliance with the administration of the preparation

Inactive Publication Date: 2006-12-14
ASAHI KASEI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention relates to a sustained-release preparation containing fasudil hydrochloride as an active ingredient. The technical effects of this invention include the ability to lower the frequency of administration of the preparation, improve compliance with the treatment, and decrease the burden of the patient who needs to take the medication. The invention also addresses the problem of controlling the release of fasudil hydrochloride from the preparation in a sustained-release form, which is conventionally difficult. Additionally, the invention addresses the issue of controlling the kinetics of fasudil hydrochloride in a living body, ensuring a satisfactory therapeutic effect.

Problems solved by technology

However, with respect to a disease (such as an ischemic disease) which should be treated by administering a drug for a long period of time, when a preparation used as a drug for treating the disease should be frequently administered, in many cases, the so-called “compliance” with respect to the administration of the preparation is low.
This low compliance is caused by the fact that when the preparation should be frequently administered, in many cases, the patient forgets to take the preparation.
As a result, the therapeutic effect of the preparation cannot be surely achieved.

Method used

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  • Oral sustained-release preparation of fasudil hydrochloride
  • Oral sustained-release preparation of fasudil hydrochloride
  • Oral sustained-release preparation of fasudil hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

reference example 1

[0194] 400 g of fasudil hydrochloride anhydride was dissolved in 600 ml of purified water to obtain an aqueous solution of fasudil hydrochloride. Using the obtained aqueous solution of fasudil hydrochloride, 350 g of NONPAREIL 105 was subjected to coating with fasudil hydrochloride by the Wurster method in the following manner. That is, 350 g of NONPAREIL 105 was charged into a LAB-1 model fluid-bed granulator (manufactured and sold by POWREX CORPORATION, Japan), which was equipped with a sprayer. The aqueous solution of fasudil hydrochloride was charged in the sprayer of the granulator. The NONPAREIL 105 was subjected to fluidization in the granulator under conditions wherein the air temperature was 80° C. and the air flow rate was 50 m3 / hr, while spraying the aqueous solution of fasudil hydrochloride into the fluid-bed of NONPAREIL 105 under conditions wherein the spraying rate was 2 ml / min and the air pressure for spraying was 2 kg / cm2 so as to coat the NONPAREIL 105 with fasudil...

reference example 2

[0195] The preparation of core member particles was conducted in substantially the same manner as in Reference Example 1 except that 400 g of fasudil hydrochloride hemihydrate was used instead of 400 g of fasudil hydrochloride anhydride and 350 g of CELPHERE CP-507 was used instead of 350 g of NONPAREIL 105, thereby obtaining 700 g of core member particles each having a particle diameter of from 600 μm to 850 μm. The same procedure as mentioned above was conducted thrice in total, so that 3 lots of the core members having a total weight of approximately 2,000 g were obtained.

reference example 3

[0196] 1,400 g of fasudil hydrochloride hemihydrate and 70 g of HPC-L were dissolved in 2,100 ml of purified water to obtain an aqueous solution of fasudil hydrochloride. Using the obtained aqueous solution of fasudil hydrochloride, 700 g of CELPHERE CP-507 was subjected to coating with fasudil hydrochloride in the following manner. That is, 700 g of CELPHERE CP-507 was charged into an MP-01 model rolling fluid-bed granulator (manufactured and sold by POWREX CORPORATION, Japan), which was equipped with a sprayer. The aqueous solution of fasudil hydrochloride was charged in the sprayer of the granulator. The CELPHERE CP-507 was subjected to fluidization in the granulator under conditions wherein the air temperature was 85° C., the air flow rate was 70 m3 / hr and the revolution rate of the rotor was 400 rpm, while spraying the aqueous solution of fasudil hydrochloride into the fluid-bed of CELPHERE CP-507 under conditions wherein the spraying rate was 8 g / min and the air pressure for s...

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Abstract

Disclosed is an oral sustained-release preparation which contains at least one active-ingredient selected from the group consisting of fasudil hydrochloride and a hydrate thereof, the preparation comprising at least one sustained-release coated particle comprising a core having a surface and a coating formed on the surface of the core, wherein the core contains the active ingredient and the coating comprises a coating base material and a specific insoluble auxiliary material, and wherein the preparation exhibits, with respect to the active ingredient, a specific dissolution rate, as measured by the dissolution test. By using the oral sustained-release preparation of the present invention, it becomes possible to surely control the release of fasudil hydrochloride from the preparation, so that the effect of the active ingredient is maintained for a long period of time. Therefore, the burden of the patient who has to take the preparation can be decreased and the compliance with respect to the administration of the preparation can be improved. Also disclosed is a method for evaluating an oral sustained-release preparation containing the active ingredient, wherein the evaluation is conducted with respect to the sustained-release ability of the active ingredient.

Description

BACKGROUND OF THE INVENTION [0001] 1. Field of the Invention [0002] The present invention-relates to an oral sustained-release preparation. More particularly, the present invention is concerned with an oral sustained-release preparation which contains at least one active ingredient selected from the group consisting of fasudil hydrochloride and a hydrate thereof, the preparation comprising at least one sustained-release coated particle comprising a core having a surface and a coating formed on the surface of the core, wherein the core contains the active ingredient and the coating comprises a coating base material and a specific insoluble auxiliary material, the preparation exhibiting a specific dissolution rate with respect to the active ingredient, as measured by the dissolution test. The present invention is also concerned with a method for evaluating an oral sustained-release preparation containing the active ingredient, the evaluation being conducted with respect to the sustain...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/26A61K9/22A61K9/50A61K31/551
CPCA61K9/501A61K9/5015A61K31/551A61K9/5047A61K9/5078A61K9/5026A61P9/08A61P9/10A61K9/20
Inventor SUGI, TOMOKAZUNISHIO, FUMIHIDE
Owner ASAHI KASEI PHARMA
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