Stable organic peroxide compositions

Inactive Publication Date: 2007-01-04
JR CHEM LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0007] Organic peroxide compositions including one or more antioxidants are described herein. These compositions exhibit excellent stability. Such compositions can be formulated into products with increased shelf life. The excellent stability also leads to product forms that were previously not obtainable, such as, for exampl

Problems solved by technology

Organic peroxides are unstable.
Instability is problematic and leads to short shelf lives, required expiration dating, h

Method used

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  • Stable organic peroxide compositions
  • Stable organic peroxide compositions
  • Stable organic peroxide compositions

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0050] A solution of benzoyl peroxide (“BPO”) was formulated in the following manner to deliver 8% benzoyl peroxide in the finished product.

IngredientAmountBenzoyl Peroxide 75% wet with water10.67 to carry in 8parts dry BPOBenzoyl benzoate40.00%

[0051] Benzoyl peroxide was dissolved into the benzyl benzoate. The resulting solution / dispersion was then added to the following materials.

IngredientAmountEthoxydiglycol10.00 parts Dimethyl Isosorbide41.1 partsButylated Hydroxytoluene (BHT) (antioxidant)0.40 partsVitamin E Acetate (antioxidant)0.50 parts

[0052] The above formulation results in a clear solution that has pharmaceutical properties.

[0053] The thermal decomposition of benzoyl peroxide results in the generation of carbon dioxide gas as well as free radicals. The amount of carbon dioxide gas given off can be used as a relative measurement of the stability of any two compositions in relationship to each other.

[0054] The formula of Example 1 was placed on stability at elevated t...

example 2

[0057] A toner composition shown below was tested using the procedure described in Example 1.

IngredientAmountBenzoyl Peroxide 75% wet with water3.33% to carry in2.5% BPO dryEthoxydiglycol25.00% Benzyl benzoate42.47% Dimethyl isosorbide21.6%Benzoic acid5.00%Salicylic acid2.00%Vitamin E Acetate 0.2%Butylated hydroxyl toluene 0.4%

[0058] The test formula above was placed on stability at elevated temperatures of 40° C. and 30° C. versus a control formulation (the same formula above without the two antioxidants). The samples were placed in glass bottles with eye droppers and checked for the amount of gas that was generated. After a month at 40° C. the control samples (the same formula above without the two antioxidants) had filled up into the rubber bulb and pressure was evident via bulb expansion. In the case of the test formula, the droppers were empty and liquid had not moved into bulb. For the 30° C. samples the control had completely filled the dropper and was present in the bulb. ...

example 3

[0059] Another formulation in accordance with the present disclosure is as follows:

IngredientAmountBenzoyl Peroxide 6.25%Benzoyl benzoate42.45%Dimethyl isosorbide40.00%Vitamin E Acetate 0.5%BHT 0.8%Ethoxy diglycol 10.0%fumed silica0-10%

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Abstract

Organic peroxide compositions are stabilized against decomposition by the use of antioxidants, resulting in increased shelf life of products made using the compositions.

Description

RELATED APPLICATION [0001] This application claims priority benefit of U.S. Provisional Application No. 60 / 695,223 filed Jun. 29, 2005, herein incorporated by reference in its entirety.BACKGROUND [0002] 1. Technical Field [0003] This disclosure relates to the preparation of compositions containing stable organic peroxide in solution. The compositions are useful for topical application to human skin and / or allow stable organic peroxides to be utilized in new product forms. Products (e.g., industrial, pharmaceutical or consumer based products) formulated using these compositions exhibit extended shelf life. Such compositions also have unique processing capabilities. [0004] 2. Background of Related Art [0005] Organic peroxides are used in many products. For example, benzoyl peroxide is used in pharmaceutical and consumer products as an active ingredient for therapeutic treatments. Organic peroxides are unstable. This instability is a desired trait when these materials are used for free...

Claims

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Application Information

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IPC IPC(8): C11D3/39
CPCA61K8/33C11D3/3947A61K8/38A61K8/4973A61K8/676A61K8/678A61K9/0014A61K31/327A61K45/06A61K47/10A61K47/22A61K2800/522A61Q19/00C11D3/0084C11D3/2034C11D3/2058C11D3/2068C11D3/2093C11D3/382C11D3/3945A61K8/347
Inventor FARYNIARZ, JOSEPH R.RAMIREZ, JOSE E.
Owner JR CHEM LLC
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