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Nucleic acid and amino acid sequences relating to Candida albicans for diagnostics and therapeutics

a technology of amino acid sequences and nucleic acids, applied in the field of isolated nucleic acids and polypeptides derived from candida albicans, can solve the problems of difficult application of powerful genetic and molecular methods, compounding with significant toxic side effects,

Inactive Publication Date: 2007-02-01
WEINSTOCK KEITH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention provides compositions and methods for detecting, treating, and preventing fungal infections, particularly C. albicans, by using nucleic acids and polypeptides specific to this organism. These compositions can be used as reagents for diagnosis, to screen for C. albicans in plants, and to develop antifungal drugs and vaccines. The invention also includes computer-readable media containing the nucleotide sequences of the invention. Overall, the invention provides new tools for diagnostics, therapeutics, and preventive measures against fungal infections."

Problems solved by technology

This creates difficulties in the application of the powerful genetic and molecular methods used in Saccharomyces and Schizosaccharomyces.
However, invasive infections are treated primarily with fluconazole, amphotericin B, and 5-fluorocytosine, although the latter two compounds have significant toxic side effects.

Method used

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Examples

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Embodiment Construction

[0052] The sequences of the present invention include the specific nucleic acid and amino acid sequences set forth in the Sequence Listing that forms a part of the present specification, and which are designated SEQ ID NO: 1-SEQ ID NO: 28206. Use of the terms “SEQ ID NO: 1-SEQ ID NO: 14103”, “SEQ ID NO: 14104-SEQ ID NO: 28206” the sequences depicted in Table 2”, and like terms, is intended, for convenience, to refer to each individual SEQ ID NO individually, and is not intended to refer to the genus of these sequences unless such reference would be indicated. In other words, it is a shorthand for listing all of these sequences individually. The invention encompasses each sequence individually, as well as any combination thereof.

Definitions

[0053]“Nucleic acid” or “polynucleotide” as used herein refers to purine- and pyrimidine-containing polymers of any length, either polyribonucleotides or polydeoxyribonucleotides or mixed polyribo-polydeoxyribo nucleotides. This includes single-...

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Abstract

The invention provides isolated polypeptide and nucleic acid sequences derived from Candida albicans that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from fungal infection.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is converted from U.S. provisional application Ser. No. 60 / 074,725, filed Feb. 13, 1998 and U.S. provisional application Ser. No. 60 / 096,409 filed Aug. 13, 1998.FIELD OF THE INVENTION [0002] The invention relates to isolated nucleic acids and polypeptides derived from Candida albicans that are useful as molecular targets for diagnostics, prophylaxis and treatment of pathological conditions, as well as materials and methods for the diagnosis, prevention, and amelioration of pathological conditions resulting from fungal infection. BACKGROUND OF THE INVENTION [0003]Candida albicans is a dimorphic fungus which has both a yeast-like growth habit and a filamentous form consisting of both hyphae and pseudohypae. The fungus is a member of the normal surface flora of most individuals. Although no sexual state has been described for C. albicans, the genome is diploid in most strains (Whelan, W L et al. (1980) Mol. Gen. Genet. 180...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07H21/04C12N1/18C12N15/74C07K14/40C12Q1/68
CPCC12Q1/6895C12Q2600/158
Inventor WEINSTOCK, KEITHBUSH, DAVID
Owner WEINSTOCK KEITH
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