Targeting Pseudotyped Retroviral Vectors

a technology of pseudotyped retroviral vectors and targeted genes, applied in the field of lentiviral vectors, can solve the problems of limited in vivo usefulness of lentiviral vectors, difficult to apply specific targeting to retroviral vectors, and few studies of retroviral vector targeting in living animals are not efficient, so as to reduce the natural tropism of sindbis virus envelope, increase the specificity of targeted gene transduction, and reduce the endogenous tropism of e2
US20080227736A1Inactive Publication Date: 2008-09-18RGT UNIV OF CALIFORNIA
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
RGT UNIV OF CALIFORNIA
Publication Date
2008-09-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to retroviral vectors, particularly lentiviral vectors, pseudotyped with Sindbis envelope and targeted to specific cell types via a targeting moiety linked to the envelope.
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Description

CROSS-REFERENCES TO RELATED APPLICATIONS

[0001] This application claims the benefit of U.S. Provisional Patent Application No. 60 / 577,248, filed Jun. 3, 2004, the disclosure of which is hereby incorporated herein by reference in its entirety for all purposes.STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT

[0002] This invention was made with Government support under Grant Nos. 5R01 DK54912-06 and 5R01AI39975-01, awarded by the National Institutes of Health. The Government has certain rights in this invention.FIELD OF THE INVENTION

[0003] The present invention relates to lentiviral vectors pseudotyped with Sindbis envelope and targeted to specific cell types via a targeting moiety linked to the envelope.BACKGROUND OF THE INVENTION

[0004] Clinically effective gene therapy protocols for various diseases would ideally utilize procedures for efficient and specific targeting of therapeutic genes to affected cells while maintaining stable transduction an...

Claims

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