Process for the production of an abuse-proofed dosage form

a technology of dosage form and production process, which is applied in the direction of biocide, heterocyclic compound active ingredients, drug compositions, etc., can solve the problems of inability to actually perform safe administration and the inability to extract active ingredients from there, etc., and achieve the effect of intense negative effect and no negative
US20080311197A1Inactive Publication Date: 2008-12-18GRUNENTHAL GMBH
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
GRUNENTHAL GMBH
Publication Date
2008-12-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a process for the production of an abuse-proofed dosage form containing, apart from one or more active ingredients with potential for abuse and optionally physiologically acceptable auxiliary substances, at least one synthetic or natural polymer (C) with a breaking strength of at least 500 N, wherein the formulation mixture is combined with a solvent for the polymer (C) at least in quantities such that the formulation mixture is at least uniformly moistened, the at least moistened composition is optionally divided into sub-portions, dried and shaped to yield the dosage form.
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Description

[0001] The present invention relates to a process for the production of an abuse-proofed solid dosage form, in which there is added to a formulation mixture containing, one or more active ingredients with potential for abuse (A) and optionally physiologically acceptable auxiliary substances (B) and at least one synthetic or natural polymer (C), which exhibits a breaking strength of at least 500 N,

[0002] a) a solvent for the polymer (C) at least in quantities such that the formulation mixture is uniformly moistened,

[0003] b) the composition which has been at least moistened in this manner is optionally divided into sub-portions,

[0004] c) the portion(s) are dried and

[0005] d) shaped to yield the dosage formBACKGROUND OF THE INVENTION

[0006] Many pharmaceutical active ingredients, in addition to having excellent activity in their appropriate application, also have potential for abuse, i.e. they can be used by an abuser to bring about effects other than those intended.

[0007] Opiates, for exampl...

Claims

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