Novel antibiotic alternatives

a technology of antibiotics and alternatives, applied in the field of new antibiotic alternatives, can solve the problems of not being cost-effective to purify this protein, and death of cellular targeted bacteria
US20090233864A1Inactive Publication Date: 2009-09-17IOWA STATE UNIV RES FOUND
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
IOWA STATE UNIV RES FOUND
Publication Date
2009-09-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to two recombinant colicin expression systems, one utilizing a yeast expression system that produces a protein that is inexpensive to purify, and the other utilizing a plasmid expression system to be used as a probiotic culture. The recombinant colicins provide effective alternatives to conventional antibiotics and may be used to improve the efficiency of pork production, and the safety of its products.
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Description

CROSS-REFERENCE TO RELATED APPLICATION

[0001] This is a Divisional Application of U.S. application Ser. No. 11 / 327,713 filed Jan. 6, 2006, which is a Continuation-in-Part Application of PCT / US05 / 08512 filed Mar. 15, 2005 which claims priority to U.S. Provisional Application Ser. No. 60 / 553,209 filed Mar. 15, 2004. This application also relates to U.S. application Ser. No. 12 / 159,235 filed Jun. 26, 2008, which is a National Phase Application of PCT / US07 / 00298 filed Jan. 8, 2007 which claims priority to U.S. application Ser. No. 11 / 327,713 filed Jan. 6, 2006. The disclosures of these applications are specifically incorporated herein by reference in their entirety.BACKGROUND OF THE INVENTION

[0002] It is estimated that over 50% of all economic losses in weaned pigs are due to Escherichia coli infections, causing either diarrhea or edema disease. In addition to the E. coli strains responsible for disease in pigs, other E. coli, as well as Salmonella, strains also colonize the intestinal tra...

Claims

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