Prophylactic agent for renal failure

a technology of renal failure and aprophylactic agent, which is applied in the direction of peptide sources, applications, extracellular fluid disorders, etc., can solve the problems of insufficient antihypertensive drugs for heart failure prophylaxis, the ineffectiveness of ace inhibitors, and the risk of acute renal failure accompanying lowering blood pressur

Inactive Publication Date: 2010-01-28
CALPIS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]In addition, the present invention provides a prophylactic agent for renal failure and functional foods

Problems solved by technology

Yet on the other hand, for heart failure induced by various primary diseases, the ACE inhibitor is not effective for all cases.
Rather there is a risk of developing acute renal failure accompanying lowering blood pressure.
It has been pointed out that careful administration is required (Saishin Igaku, 48:1404 to 1409, 1993), That is, the antihypertensive drug can be insufficient for the prophylaxis of heart failure but also could rather induce renal failure.
Yet it has pointed out that the ACE inhibitors could cause acute renal failure and aggravation of renal damage.
As described above, because renal failure is caused by various factors

Method used

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  • Prophylactic agent for renal failure

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examples

Example of Peptide Synthesis

[0074]The active ingredient according to the present invention Ile Pro Pro and Val Pro Pro were synthesized by the following chemical synthesizing method (Fmoc method). The synthesis was carried out by solid phase method using an automatic peptide synthesizer (PSSM-8type) manufactured by Shimadzu Corporation.

[0075]As a solid phase carrier, 50 mg of a resin (SynProPep Resin®, manufactured by Shimadzu Corporation) which is a 2-chlorotrityl(2-Chlorotrityl)type polystyrene resin in which proline protected its amino group with a fluorenymethyloxy carbonyl group (hereinafter referred to as Fmoc for short) is bound, was used. According to the above described amino acid sequence, Fmoc-Ile, Fmoc-Pro, and Fmoc-Val (100 μmol each) which are protected their amino group with the Fmoc group were reacted in the order of the peptide sequence to obtain a peptide-bound resin in accordance with a conventional method.

[0076]This peptide-bound resin was then suspended in 1 ml ...

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PUM

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Abstract

The present invention provides an agent having a suppressive action against kidney glomerular disease and renal arteriosclerosis, a prophylactic agent for renal failure containing the above described agent, and functional foods expected to have a prophylactic effect for renal failure. The agent for preventing kidney glomerular disease and renal arteriosclerosis comprises Xaa Pro Pro as an active ingredient.

Description

FIELD OF THE INVENTION[0001]The present invention relates to an active ingredient having an action for preventing kidney glomerular diseases and renal arteriosclerosis, a prophylactic agent for renal failure containing the active ingredient, as well as functional foods containing the active ingredient, which functional food are expected to have a prophylactic effect on renal failure.[0002]In addition, the present invention relates to a method for preventing kidney glomerular diseases and renal arteriosclerosis. Further, the present invention relates to a method for preventing renal failure.BACKGROUND OF THE INVENTION[0003]Recently, the number of those who have a risk factor considered to cause heart diseases or renal diseases, such smoking, hypertension, hyperglycemia, and hyperlipidemia, have increased in some countries. There is an increasing trend in the number of patients suffering from heart failure or renal failure. In addition, these pathologic states are not limited to human...

Claims

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Application Information

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IPC IPC(8): C07K5/08A61P1/16A61P7/00A23L33/10A23L33/17A23L33/19A61K35/20A61K35/74A61K35/747A61K36/06A61K38/00A61K38/01A61K38/02A61K38/06A61K38/17A61P9/00A61P9/04A61P43/00C07K14/47C12P21/06
CPCA23L1/3053A23V2002/00A61K38/06A23V2200/326A23V2250/0654A23V2250/064A23V2200/32A23V2250/0626A23L33/18A61P1/16A61P7/00A61P9/00A61P9/04A61P9/10A61P13/12A61P43/00
Inventor HIROTA, TATSUHIKOOHKI, KOHJINAKAMURA, TEPPEITAKANO, TOSHIAKI
Owner CALPIS
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