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Method for administering a spill resistant pharmaceutical system

a pharmaceutical system and spill-resistant technology, applied in the field of pharmaceutical compositions for administering pharmaceuticals orally, can solve the problems of inability to accurately measure the dose, and inability to administer a prescribed dose, etc., to achieve the effect of convenient measurement, convenient swallowing, and stable components

Inactive Publication Date: 2010-03-11
TARO PHARMA INDS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The system provides a stable, spill-resistant, and easy-to-administer semi-solid formulation that maintains its properties over time, ensuring accurate dosing and ease of use for all ages, including those with motor difficulties, with improved shelf life and palatability.

Problems solved by technology

These liquid formulations are typically measured by pouring into a spoon, but this approach has the great drawback of spillage.
The risk of spillage can cause people to underfill the spoon, leading to inaccurate dosage.
With elderly people, children, and the infirm, difficulty in filling a spoon with a liquid and bringing it to the mouth can be a serious impediment to administering the medicine.
Solid formulations such as pills, tablets, and capsules are also difficult for children and for elderly, infirm people to swallow.

Method used

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  • Method for administering a spill resistant pharmaceutical system
  • Method for administering a spill resistant pharmaceutical system
  • Method for administering a spill resistant pharmaceutical system

Examples

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examples

[0058]To compare the drug delivery system of the invention to other technologies, experiments were conducted with the goal of identifying and quantifying the relevant physico-chemical characteristics of formulations according to the invention. These were compared to characteristics of other formulations that are commercially available or disclosed in the prior art. The results indicate that the properties of the pharmaceutical compositions herein have surprising advantages and critical characteristics necessary for a non-spill drug delivery system and that the other tested products are unsatisfactory for this system.

[0059]Materials and Methods

[0060]TEST SAMPLES (Examples 21 to 31): Laboratory scale (100 g-500 g) batches of pharmaceutical formulations were prepared essentially according to the methods and compositions described in examples 2-4, 7, 9, 11-13, 15-16, and 18 of the earlier Ross application, U.S. Ser. No. 08 / 114,315. These compositions were tested for the new acceptance c...

example 2

Pseudoephedrine HCl Formulation Thickened with Polyethylene Glycols

[0063]

Ingredient%Pseudoephedrine HCl0.6Propylene Glycol25.0Polyethylene Glycols73.5(PEG 400:PEG 3350 3:1)Methyl Paraben0.22Sodium Saccharin0.20Strawberry Flavor0.05D&C Red #330.0057Purified water to100

[0064]PEG with a molecular weight less than 800 is a solid and works as a thickener and over 800 is a liquid. Thus, in S.N. 21, about 18% of the formulation is PEG 3350 (a liquid) and about 55.5% is PEG 400 (a thickener).

[0065]S.N. 22:

example 3

Acetaminophen Formulation Thickened with Carboxymethylcellulose

[0066]

Ingredient%Acetaminophen3.2Glycerin4.0Propylene Glycol25.0Sodium Saccharin0.2Methyl Paraben0.22Sodium Carboxymethylcellulose2.4Purified water to100

[0067]S.N. 23:

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Abstract

A method for administering a spill-resistant pharmaceutical formulation comprises delivery from a squeezable container of a pharmaceutical agent in a suitable vehicle comprising a liquid base and a thickening agent.

Description

[0001]This application is a continuation of U.S. Ser. No. 10 / 653,149, filed on Sep. 3, 2003, which is a continuation of U.S. Ser. No. 10 / 052,462, now U.S. Pat. No. 6,656,482, filed on Jan. 23, 2002, which is a divisional of U.S. Ser. No. 09 / 549,148, now U.S. Pat. No. 6,399,079, filed on Apr. 13, 2000, which is a continuation of U.S. Ser. No. 09 / 089,360 now U.S. Pat. No. 6,071,523, filed on Jun. 3, 1998. Each of these applications is hereby incorporated by reference in its entirety and for all purposes.BACKGROUND OF THE INVENTION[0002]The invention relates to compositions for administering pharmaceuticals orally without spilling. More specifically, the invention relates to vehicles and devices for delivering a variety of pharmaceutical products.[0003]Syrups, elixirs, solutions, and suspensions are traditional dosage forms for oral medication. These liquid formulations are typically measured by pouring into a spoon, but this approach has the great drawback of spillage. The risk of spi...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/60A61K47/30A61K31/16A61K31/192A61K31/135A61K31/439A61K31/195A61K31/445A61K31/496A61K31/551A61K31/4196A61K31/522A61K31/554A61P43/00A61K9/107A61J7/00A61K9/00A61K9/06A61K31/09A61K31/133A61K31/136A61K31/138A61K31/166A61K31/198A61K31/222A61K31/341A61K31/366A61K31/41A61K31/485A61K31/5517A61K33/00A61K38/00A61K47/10A61K47/32A61K47/36A61K47/38A61P1/08A61P1/10A61P3/02A61P3/06A61P9/00A61P11/08A61P11/10A61P11/14A61P25/00A61P25/04A61P29/00A61P31/00A61P35/00
CPCA61J7/0015A61K47/38A61J7/0053A61K9/0056A61K9/0095A61K9/06A61K31/00A61K47/02A61K47/10A61K47/12A61K47/18A61K47/22A61K47/32A61K47/36A61J7/0023A61P1/08A61P1/10A61P11/08A61P11/10A61P11/14A61P25/00A61P25/04A61P29/00A61P3/02A61P31/00A61P35/00A61P3/06A61P43/00A61P9/00
Inventor MEHTA, RAKESHMOROS, DAN
Owner TARO PHARMA INDS
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