Novel Cellular Compositions and Methods for Their Preparation

a cell composition and cell technology, applied in the field of new cell compositions, can solve the problems of erratic source, limited availability of hepatocytes, development of bioartificial livers,
US20100075295A1Inactive Publication Date: 2010-03-25IN VITRO TECH
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
IN VITRO TECH
Publication Date
2010-03-25
Estimated Expiration
Not applicable · inactive patent
Patent Text Reader

Abstract

The present invention relates to novel cell (e.g., hepatocyte, etc.) compositions and methods for their preparation and use. In particular, the invention concerns methods of processing preparations of such cells so as to permit their repeated cryopreservation and thawing while retaining substantial viability. The invention also concerns preparations of cells (e.g., hepatocytes) that have been repeatedly cryopreserved and thawed.
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Description

[0001] This application is a continuation of U.S. patent application Ser. No. 11 / 110,879, filed Apr. 21, 2005, which application is herein incorporated by reference in its entirety.FIELD OF THE INVENTION

[0002] The present invention relates to novel cell (e.g., hepatocyte, etc.) compositions and methods for their preparation and use. In particular, the invention concerns methods of processing preparations of such cells so as to permit their repeated cryopreservation and thawing while retaining substantial viability. The invention also concerns preparations of cells (e.g., hepatocytes) that have been repeatedly cryopreserved and thawed.BACKGROUND OF THE INVENTION

[0003] Hepatocytes are parenchymal liver cells, and make up 60-80% of the cytoplasmic mass of the liver. Hepatocytes play a key role in the detoxification, modification and excretion of exogenous and endogenous substances (Ponsoda, X. et al. (2004) “Drug Metabolism By Cultured Human Hepatocytes: How Far Are We From The In Vivo Re...

Claims

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