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Promotors of Ceramide's Generation

Inactive Publication Date: 2011-08-18
ZHONGSHAN HOSPITAL FUDAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0011]The present invention provides pharmaceuticals, cosmetics, and the like for accelerating intracellular ceramide production. In addition, the present invention provides cosmetics or pharmaceuticals capable of restoring or maintaining barrier function and moisturizing function of skin.
[0019]The ceramide production-accelerating agent of the present invention increases intracellular ceramide and is useful as pharmaceuticals, and the like, for preventing or ameliorating inflammatory disease, bone and joint disease, periodontal disease, and the like, or as cosmetics, and the like, for giving body and strength to hair and improving the feeling thereof.

Problems solved by technology

However, problems included in this method are, for example, difficulty of long-term effect and low stability, and the like.
However, it has not so far been known that these plants show a ceramide production-accelerating effect and a moisturizing effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

Preparation of Angelicae Dahuricae Radix Extract

[0037]To 100 g of Angelicae Dahuricae Radix, 5 times amount of petroleum ether was added, and the mixture was stirred for 1 hour at 50° C., followed by extraction and filtration, to prepare a petroleum ether extract. Then the petroleum ether extract was evaporated and dried, to yield approximately 0.9 g of petroleum ether extract of Angelicae Dahuricae Radix.

preparation example 2

Preparation of Rehmanniae Radix Extract

[0038]Following the same procedure as Preparation Example 1, except that 100 g of Rehmanniae Radix was used in place of 100 g of Angelicae Dahuricae Radix, a petroleum ether extract was prepared. To the residue prepared by the extraction with the petroleum ether, 5 times amount of 95% ethanol was added, and the mixture was refluxed with stirring at 78° C. for 1 hour, followed by extraction and filtration, to prepare an ethanol extract. Then the ethanol extract was evaporated and dried, to yield approximately 5.0 g of ethanol extract of Rehmanniae Radix.

preparation example 3

Preparation of Atractylodis Rhizoma Extract

[0039]Following the same procedure as Preparation Example 1, except that 100 g of Atractylodis Rhizoma was used in place of 100 g of Angelicae Dahuricae Radix, a petroleum ether extract was prepared. The petroleum ether extract was evaporated and dried, to yield approximately 0.8 g of petroleum ether extract of Atractylodis Rhizoma.

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PUM

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Abstract

The present invention provides a pharmaceutical composition or a cosmetic product which can accelerate production of ceramide in cells. The ceramide production-accelerating agent contains a plant selected from the group consisting of Radix Heraclei Scabridi, Rhizoma Dioscoreae, Radix Rehmanniae, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Radix Et Rhizoma Rhei, Pseudobulbus Bletillae, Radix Polygoni Multiflori, Radix Platycodi, and Herba Leonuli, or an extract thereof as an active ingredient. Further, the present invention provides a moisturizing agent containing a plant selected from the group consisting of Herba Leonuri and Rhizoma Dioscoreae, or an extract thereof as an active ingredient.

Description

FIELD OF THE INVENTION[0001]The present invention relates to a ceramide production-accelerating agent which can increase ceramide.BACKGROUND OF THE INVENTION[0002]Ceramide, which is a sphingolipid, is a lipid contained only in a small amount in whole living body. It has recently been reported that phenomena, such as proliferation, differentiation, and growth inhibition are induced by enhancing production of intracellular ceramide, and thus ceramide is an attractive intracellular signaling molecule capable of controlling proliferation, differentiation, apoptosis, and the like, of cells. Accordingly, it is thought that a ceramide production-accelerating substance is expected to have effects such as suppression of proliferation, induction of differentiation, and induction of apoptosis of animal cells, and consequently is expected to have therapeutic effects on diseases caused by abnormality of proliferation or differentiation of cells, such as inflammatory diseases and malignant tumors...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61K36/232A61K36/64A61K36/284A61K36/898A61K36/704A61K36/346A61K36/53A61K36/8945A61P17/00A61P35/00A61P29/00A61P19/00
CPCA61Q19/00A61K8/97A61K8/9794A61P17/00A61P17/16A61P19/00A61P29/00A61P35/00A61P43/00A61K36/232A61K36/284A61K36/346A61K36/484A61K36/533A61K36/64A61K36/70A61K36/708A61K36/8945A61K36/898
Inventor QIN, WAN ZHANGYANG, CHUN XINKONG, FAN QINOJIRI, HIROSHIITO, SHOTARO
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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