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Sorption reinforced catalytic coating system and method for the degradation of threat agents

a technology of threat agent and coating system, which is applied in the direction of enzymology, transportation and packaging, synthetic resin layered products, etc., can solve the problems of death soon after exposure, and inability to provide comprehensive protection for personnel working in dry and wet environments. achieve the effect of maximizing the loading and retention of one or more enzymes

Inactive Publication Date: 2012-06-14
FOSTER-MILLER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes a reinforced catalytic coating system for the degradation of threat agents, such as chemical weapons or radiological threat agents. The system includes a polyurethane coating that provides stability and loading of enzymes that can degrade the threat agents. An enzyme coating is placed on top of the polyurethane coating to further enhance the system's ability to degrade threat agents. A binding agent is used to immobilize the enzymes for better retention and stability. The coating system can be used to make protective clothing or other protective materials. The invention also includes a method for making the reinforced catalytic coating system.

Problems solved by technology

It is known that an extremely small amount of a CWA, such as a nerve agent, can affect the transmission of chemical nerve impulses in humans leading to death soon after exposure.
However, to date, there is no single solution to provide comprehensive protection for personnel working in both dry and wet environments.
However, such a method often generates side-reactions which can reverse to form the original toxic chemical agents.
More recently biological catalysts have been developed which rapidly and safely decontaminate CWAs or TICs but have limited life spans because of their fragile nature.
However, such a technique causes a major loss of enzyme activity.
However, most of the enzymes incorporated into the sponge were eventually rendered inactive during the polymerization process.
However, even this layer-by-layer approach has some distinct drawback.

Method used

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  • Sorption reinforced catalytic coating system and method for the degradation of threat agents
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  • Sorption reinforced catalytic coating system and method for the degradation of threat agents

Examples

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examples

[0057]The following examples are meant to illustrate and not limit the various embodiments of the present invention.

[0058]Novel sorption reinforced catalytic systems, capable of decontaminating CWAs and TICs, have been conceived and demonstrated.

[0059]These new catalytic systems and methods discussed herein may be based on enzyme bearing polymeric composites. These new systems have the added benefit of maximizing the enzyme loading while stabilizing the naturally fragile enzyme to maintain its catalytic activity by preventing its denaturing. Unique methods and compositional approaches that produce catalytic systems that chemically degrade CWA and TIC compounds in water and air have been demonstrated.

[0060]The systems and methods discussed herein create a robust absorptive enzyme support material from polymerizable pre-polymers to safely harbor the enzyme while maintaining its catalytic activity against CWAs and TICs. Enzymes are easily denatured and maintaining their catalytic activ...

example i

Synzyme Coating

[0065]Amines are a well known group of weak nucleophilic compounds with a wide set of basic reactions which they participate in, but being relatively weak nucleophiles they are not capable of reacting with organophosphates and the like at ambient conditions, which requires a stronger nucleophile for a reaction to occur. But even with such limitations their chemical properties and reactivities can be changed by taking the monomeric amines and polymerizing them into chains which contain a large concentration of primary, secondary and tertiary amines. These new polymeric amines have been shown to exist in extensive branched networks. Branched polyethylenemine (BPEI), and shorter straight chain oligomeric amines, show an increased reactivity towards a wider spectrum of substrates. Once the amines are in this new polymerized form they have shown the ability to catalyze the hydrolysis of organophosphates without the amines themselves being used up in the reaction.

[0066]Labo...

example ii

Sorption Reinforced Self-Decontaminating Polymeric Bio-Catalytic System Against Chemical Warfare Agents (CWA)

[0072]One purpose of one or more embodiments of this invention is to develop sorption-reinforced, self-decontaminating enzyme-polymeric coatings for military uniforms (fabrics imbedded with particles) capable of providing comprehensive protection at low and high temperatures against nerve, blister and microbial agents. Currently no known enzyme catalytic system is available which allows for: 1) recycled use through self-repairing (refolding) technology, 2) to decontaminate chemical agents followed by subsequent sequestering of break down products for safe disposal, 3) protection against blister agents (sulfur mustard) without producing geno-toxic intermediates, and 4) increased protection by maximizing the loading and locking of catalytic enzymes and nucleophilic polymers at low temperature environments (4° C.) as well as at ambient conditions. The system and method of one or...

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Abstract

Sorption reinforced catalytic coating system for the degradation of threat agents including a synzyme coating about a material, the synzyme coating having bucket-shaped molecules for the sorption and degradation of the threat agents. A binding agent is configured for synzyme immobilization to maximize loading and retention of the synzyme coating on the material.

Description

RELATED APPLICATIONS[0001]This application hereby claims the benefit of and priority to U.S. Provisional Application Ser. No. 61 / 281,900, filed on Nov. 24, 2009 under 35 U.S.C. §§119, 120, 363, 365, and 37 C.F.R. §1.55 and §1.78, incorporated by reference herein.FIELD OF THE INVENTION[0002]This invention relates to a sorption reinforced catalytic coating system and method for the degradation of threat agents.BACKGROUND OF THE INVENTION[0003]Chemical, Radiological, Biological and Nuclear Defense (CRBN) is a high priority of the Army and National Security due to rogue states and the rise of terrorist organizations that are technologically sophisticated, well-financed and committed to inflicting damage on U.S. interests and personnel. The increased threat of chemical and biological agent attack in various military theaters combined with the possibility of terrorist attacks on the general public has led the inventors hereof to evaluate protective equipment for military and civil defense...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): B32B27/40B05D3/10
CPCC12N11/08C12N11/06C12N11/089C12N11/093Y10T428/31551
Inventor LEE, YONGWOOMODZELEWSKI, TOMASZPUGLIA, JOHN P.WEISS, STEVEN E.REINSTEIN, ROBERT A.
Owner FOSTER-MILLER