Tumor treatment

a tumor and tumor technology, applied in the field of tumor treatment, can solve the problem that the inhibition of thymidylate synthase alone is likely approaching the limit of colorectal cancer efficacy, and achieves the effect of improving the effect of thymidylate synthase and the effect of reducing the risk of cancer

Inactive Publication Date: 2012-08-09
POLAKIS PAUL
View PDF0 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This approach enhances the effectiveness of cancer treatments by specifically targeting genes activated by chemotherapeutic agents in tumor cells, potentially leading to improved patient response and prognosis by inhibiting tumor growth and overcoming treatment resistance.

Problems solved by technology

However, inhibition of thymidylate synthase alone is likely approaching a limit with respect to efficacy in colorectal cancer (Ragnhammer et al.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Tumor treatment
  • Tumor treatment
  • Tumor treatment

Examples

Experimental program
Comparison scheme
Effect test

example

Treatment of Human Colorectal Tumor Xenografts with Irinotecan (CPT-11) Activates Genes Normally Expressed by Squamous Cell Epithelium

[0168]This study was designed to identify gene transcripts acutely expressed by human colorectal adenocarcinomas following in vivo exposure to the standard care chemotherapeutic irinotecan. Colo205 and DLD-1 xenografts were used as p53 wild-type (wt) and p53 mutant tumor models, respectively, and gene expression by normal murine colon tissue resected from the same animals was also analyzed. The expression levels of numerous transcripts were reproducibly altered by drug treatment of the tumors, including, but not limited to, the genes normally expressed by squamous cell epithelium.

[0169]Materials and Methods

[0170]Cell lines—Colo205, HCT116, HT29 (ATCC Nos. CCL222, CCL221, CCL247, HTB38, respectively) are human colorectal adenocarcinoma cell lines. 293 is a human immortalized embryonic kidney cell line (ATCC CRL1573). PC-3 is a human prostate adenocarci...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention concerns an improved method for treating tumor, including cancer, which combines the administration of a chemotherapeutic agent and an antagonist of a gene product the expression of which is upregulated by the chemotherapeutic agent. The invention further concerns methods and means for the diagnosis and classification of tumors, and for the prognosis of the outcome of tumor treatment, and patient response to a particular treatment modality.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This is a non-provisional application filed under 37 C.F.R. 1.53(b), claiming priority under U.S.C. Section 119(e) to Provisional Application Ser. No. 60 / 580,745, filed on Jun. 18, 2004.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention relates to the treatment of tumor. In particular, the invention concerns an improved method for treating tumor, including cancer, which combines the administration of a chemotherapeutic agent and an antagonist of a gene product the expression of which is upregulated by the chemotherapeutic agent. The invention further concerns methods and means for the diagnosis and classification of tumors, and for the prognosis of the outcome of tumor treatment, and patient response to a particular treatment modality.[0004]2. Description of the Related Art[0005]Colorectal cancer is a leading cause of cancer mortality in Westernized countries accounting for over 50,000 deaths per year in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & AuthorityApplications(United States)
IPC IPC(8): A61K39/395A61P35/00A61K31/7052C40B30/04A61K31/437A61K38/02
CPCA61K31/4745A61K31/513A61K31/522A61K31/525A61K31/7072A61K31/7076A61K45/06C12N2799/022C07K16/30A61K2039/505A61K2300/00A61P35/00A61P35/04A61P43/00
InventorPOLAKIS, PAUL
OwnerPOLAKIS PAUL