Method for the production of amorphous rifaximin

a technology of rifaximin and amorphous form, which is applied in the field of amorphous rifaximin production, can solve the problems of change form, unstable several forms, and serious consequences on maintaining the desired properties, and achieves the effects of increasing the solubility of amorphous forms, enhancing drug bioavailability, and increasing the solubility valu
US20120289532A1Active Publication Date: 2012-11-15UNILAB S A S DI LAVAGNA SILVIO MASSIMO & C
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Patent Information

Authority / Receiving Office
US ยท United States
Patent Type
Applications(United States)
Current Assignee / Owner
UNILAB S A S DI LAVAGNA SILVIO MASSIMO & C
Publication Date
2012-11-15

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Abstract

The present invention relates to a new amorphous form of rifaximin and to methods for the preparation thereof by means of high energy milling or Spray drying. The present invention further relates to a new amorphous form for use as medicament and to the pharmaceutical compositions composing it.
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Description

[0001] The present invention relates to a new amorphous form of rifaximin and to methods for the production thereof by means of high energy milling or Spray drying. The present invention also relates to the new amorphous form for use as a medicament and to the pharmaceutical compositions comprising it.STATE OF PRIOR ART

[0002] The phenomenon of polymorphism in chemistry is generated by the possibility that the same molecule organizes in different (polymorphic) crystals, crystallizes with solvent molecules (hydrates and solvates) or solidifies without periodicity (amorphous). The different crystalline or amorphous phases, even if they contain the same active molecule, can have even very different chemical, physical and mechanical properties with huge consequences upon the use thereof as active principles. In particular different solid forms show different chemical activities against other substances, which explicates with particular evidence in case of solvent or dispersing agents. Furt...

Claims

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