Release reagent for vitamin d compounds

a technology of vitamin d and reagents, which is applied in the field of vitamin d release reagents, can solve the problems of vitamin d having a relatively short biological half-life in the circulation, affecting the d status of patients, and the measurement of the vitamin d level itself is of little benefi
US20130078729A1Inactive Publication Date: 2013-03-28ROCHE DIAGNOSTICS OPERATIONS INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
ROCHE DIAGNOSTICS OPERATIONS INC
Publication Date
2013-03-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein, an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition and the reagent mixture obtained in this manner. The use of the disclosed reagent composition to release vitamin D compounds as well as a kit for detecting a vitamin D compound which contains the reagent composition for releasing vitamin D compounds in addition to common detecting reagents.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation of International Application No. PCT / EP2011 / 058048, filed May 18, 2011, which claims the benefit of European Patent Application No. 10163453.3, filed May 20, 2010, and European Patent Application No. 11158296.1, filed Mar. 15, 2011, the disclosures of which are hereby incorporated by reference in their entirety.BACKGROUND OF THE DISCLOSURE

[0002] An adequate supply of vitamin D is vital as the term “vitamin” already suggests. A deficiency of vitamin D leads to severe diseases such as rickets or osteoporosis. While vitamin D was still regarded as a single substance at the beginning of the last century, the vitamin D system has changed in the course of the last decades into a complex and manifold network of vitamin D metabolites. Nowadays more than 40 different vitamin D metabolic products are known (Zerwekh, J. E., Ann. Clin. Biochem. 41 (2004) 272-281).

[0003] Humans can only produce D3 vitamins or calcifero...

Claims

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