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Extracts and isolated flavonoids from euphorbia cuneata useful as Anti-ulcer agents

a technology of euphorbia cuneata and flavonoids, which is applied in the field of extracting and isolated flavonoids from euphorbia cuneata, can solve the problems of many side effects and poisonous latex

Inactive Publication Date: 2013-03-28
KING SAUD UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a method for isolating antiulcerogenic active compounds from natural materials like Euphorbia cuneata. This method is flexible and can easily obtain the desired substances or extracts from this natural material.

Problems solved by technology

The use of plants as a therapeutic agent is well known from the previous decades, however, when man developed synthesized drugs led to many side effects.
The latex is poisonous in some species and many of them contain irritant and pesticidal substances.

Method used

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  • Extracts and isolated flavonoids from euphorbia cuneata useful as Anti-ulcer agents

Examples

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example 1

[0044]Recovery of Plant Materials: The aerial parts of E. cuneata (Euphorbiaceae) were collected during flowering stage in 2010, from Desert of Saudi Arabia. The sample was kindly identified by Dr. M. Gebali, botanist and by comparison with the published plant description (El-Gohary, 2004). Plant material was air-dried in shade, reduced to fine powder, packed in tightly closed containers and stored for phytochemical and biological studies.

example 2

[0045]Phytochemical Screening: Powdered samples of the aerial parts of Euphorbia cuneata, Vahl were subjected to preliminary phytochemical screening according to the published methods (Awaad, 2009).

example 3

[0046]Extraction: One kilogram of the air dried powder of E. cuneata (aerial parts) was extracted by percolation in 90% ethanol at room temperature for two days and subsequent filtration. The residue was re-percolated again. The combined ethanol extracts were concentrated under reduced pressure at a temperature not exceeding 35° C. to yield a dry extract (290 g). Water (400 ml) was added and the resultant mixture successively extracted with diethyl ether, chloroform, ethyl acetate, and n-butanol respectively. Each extract was dried over anhydrous sodium sulphate, and concentrated under reduced pressure at a temperature not exceeding 35° C. to yield dry extracts (5.5, 6, 18.5 and 60 g) respectively. All extracts were tested for their antiulcerogenic and antioxidant activities. The ethyl acetate and n-butanol extracts were the most effective extracts.

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Abstract

The present invention relates to flavonoids isolated from Euphorbia cuneata, a method for their isolation, extracts from Euphorbia cuneata and a pharmaceutical composition comprising the flavonoids or the extracts or both of them for a use as anti-ulcer agent.

Description

[0001]The present invention relates to flavonoids isolated from Euphorbia cuneata, a method for isolation thereof, extracts from Euphorbia cuneata and a pharmaceutical composition comprising the flavonoids or the extracts or both of them.INTRODUCTION[0002]The use of plants as a therapeutic agent is well known from the previous decades, however, when man developed synthesized drugs led to many side effects. To minimise or avoid the side effects of synthesized drugs man return back to nature in order to discover natural curing agents. Euphorbiaceae is one of the largest plant families (321 genera and 7950 species) and most of its species contain a milky or colored latex. The latex is poisonous in some species and many of them contain irritant and pesticidal substances. The genus Euphorbia constitutes the largest number of this family. It comprises 700 species of trees, shrubs or herbs with acrid milky juice.[0003]This genus is of great importance due to its various phytochemical const...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P1/04A61K31/352C07D311/30C07H17/04
CPCA61K31/7048A61K36/47A61K2236/30C07H17/07A61K31/352C07D311/40A61K31/353A61P1/04
Inventor AWAAD, AMANI S.EL-MELIGY, REHAM MOUSTAFA
Owner KING SAUD UNIVERSITY
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