System and method for assessing renal artery nerve density

a technology of renal artery nerve density and assessment method, which is applied in the field of nerve placement, can solve the problems of significant blood pressure decline, heart failure, kidney disease, etc., and achieve the effect of maximizing the degree of denervation

Inactive Publication Date: 2013-08-22
PACESETTER INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010]Embodiments of the invention provide a method and system to map the renal artery prior to the ablation in order to a-priori identify the location of the sympathetic nerves. This method then allows the clinician to target the ablation procedure, and maximize the degree of denervation. In specific embodiments, one or more parameters are monitored to assess the nerve density in different areas of the renal artery or similar blood vessel.

Problems solved by technology

Chronic over-activation can result in vascular and myocardial hypertrophy and insulin resistance, causing heart failure and kidney disease.
The results included radiographic evidence of hearts that had remodeled after the surgery, while also showing significant blood pressure declines.
However, given the highly invasive and traumatic nature of the procedure and the advent of more effective antihypertensive agents, the procedure was not widely employed.
This degree of variability poses a particular challenge to the clinician trying to ablate the nerves.

Method used

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  • System and method for assessing renal artery nerve density
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  • System and method for assessing renal artery nerve density

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Embodiment Construction

[0032]In the following detailed description of the invention, reference is made to the accompanying drawings which form a part of the disclosure, and in which are shown by way of illustration, and not of limitation, exemplary embodiments by which the invention may be practiced. In the drawings, like numerals describe substantially similar components throughout the several views. Further, it should be noted that while the detailed description provides various exemplary embodiments, as described below and as illustrated in the drawings, the present invention is not limited to the embodiments described and illustrated herein, but can extend to other embodiments, as would be known or as would become known to those skilled in the art. Reference in the specification to “one embodiment”, “this embodiment”, or “these embodiments” means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment of the invention, ...

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Abstract

A system and method is described to map the renal artery prior to an ablation in order to a-priori identify the location of the sympathetic nerves. In specific embodiments, the nerve modulating energy may be electrical or optical.

Description

FIELD OF THE INVENTION[0001]The present invention relates generally to locating nerves in blood vessels, and more specifically to an assessment method for renal artery nerve density.BACKGROUND OF THE INVENTION[0002]Hypertension (HTN), or high blood pressure (HBP), is defined as a consistently elevated blood pressure (BP) greater than or equal to 140 mmHg systolic blood pressure (SBP) and 90 mmHg diastolic blood pressure (DBP). Hypertension is a “silent killer” that is not associated with any symptoms and in 95% of cases (primary hypertension) the specific cause is unknown. In the remaining 5% of patients (secondary hypertension), specific causes including chronic kidney disease, diseases of the adrenal gland, coarctation of the aorta, thyroid dysfunction, alcohol addiction, pregnancy or the use of birth control pills are present. In secondary hypertension, when the root cause is treated, blood pressure usually returns to normal.[0003]Hypertension is a disease that affects 74.5 milli...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B5/0205A61N5/06A61N1/36A61B5/05A61B6/00
CPCA61B5/4035A61B2018/0212A61B5/02007A61B5/6852A61N1/36057A61B5/021A61B5/024A61B5/4047A61B5/4836A61B5/4848A61B18/1492A61B18/24A61B2017/00057A61B2017/00778A61B2018/00404A61B2018/00434A61B2018/00511A61B2018/00577A61B2018/00648A61B2018/00839A61B5/4893A61B5/0036
Inventor CHOLETTE, MARTINDULAK, GARY R.
Owner PACESETTER INC
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