Combination of Components for the Prevention and Treatment of Frailty

a technology of frailty and components, applied in the direction of sugar derivatives, biocide, plant growth regulators, etc., can solve the problems of increasing the risk of acquiring a health problem, and achieve the effect of effective treatment of frailty and increased bmi

Inactive Publication Date: 2013-12-12
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0030]It has now been found that lean body mass (LBW) or the body mass index (BMI) can be increased in frail mammals, or frailty can effectively be treated therapeutically or prophylactically by providing a nutritional or pharmaceutical composition comprising a specific combination of active components. Accordingly, the present invention relates to a composition comprising at least two, preferably three, and more preferably four components (as active ingredients) selected from the group of (i) a nucleoside equivalent, (ii) an ω-3 polyunsaturated fatty acid selected from the group of DHA, DPA and EPA, (iii) a vitamin B, (iv) a phospholipid, (v) an antioxidant and (vi) a choline, with the proviso that at least component (i) or (iii) is present, for use in the prevention or treatment of (pathological) frailty in a mammal, in particular for use in increasing one or more of body weight, body mass index, and lean body weight, especially in a human, especially in an elderly human.

Problems solved by technology

The combination can be used for increasing body weight for a medical reason, in particular can be administered to a subject that is underweight and as a result thereof has a medical problem, or has an increased risk of acquiring a health problem.

Method used

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  • Combination of Components for the Prevention and Treatment of Frailty
  • Combination of Components for the Prevention and Treatment of Frailty

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0222]APP / PS1 mice, a mouse model for AD, were provided with a diet enriched with DHA and UMP (intake per day: DHA=22.8 mg; UMP=23.1 mg) or with a control diet for 3 months The two diets were isocaloric and differed only with respect to DHA and UMP content The amount of fat, carbohydrates and protein was the same between diets. During the 3 months of diet intervention body weight was monitored as was food intake.

[0223]Results. Mice fed the enriched diet showed—on average—a 17.5% increase in body weight after 3 months compared to 14% for the control mice. Food intake was slightly lower in the group which were fed the enriched diet (on average 2.88 gram per day) compared to control mice (on average 3.08 gram per day).

[0224]Conclusion. Alzheimer's disease mice showed an increase in body weight when fed with the composition according to the invention (the ω-3 polyunsaturated fatty acid DHA and the nucleoside UMP), not attributed to a caloric increase in body weight.

example 2

[0225]APP / PS1 mice, a mouse model for AD, were provided with a diet enriched with B-vitamins (B6, B12 and folic acid; intake per day: B6=0.1 mg; B12=0.11 μg; folic acid=18.1 μg), phospholipids (lecithin; intake per day: 12.4 mg) and antioxidants (vitamin C, vitamin E, selenium; intake per day: vitamin C=4.8 mg; vitamin E=4.5 mg; selenium=3.2 μg) or with a control diet for 3 months. The two diets were isocaloric and differed only with respect to B-vitamins, phospholipids and antioxidants content. The amount of fat, carbohydrates and protein was the same between diets. During the 3 months of diet intervention body weight was monitored as was food intake.

[0226]Results. Mice fed the B-vitamins+phospholipids+antioxidants enriched diet showed a 18% increase in body weight after 3 months compared to 14% for the control mice. Food intake was slightly lower in the B-vitamins+phospholipids+antioxidants group (on average 2.86 gram per day) compared to control mice (on average 3.08 gram per day...

example 3

[0228]APP / PS1 mice, a mouse model for AD, were provided with a diet enriched with DHA+UMP (intake per day: DHA=22.8 mg; UMP=23.1 mg) (as in Example 1), B-vitamins (B6, B12 and folic acid; intake per day: B6=0.1 mg; B12=0.11 μg; folic acid=18.1 μg), and phospholipids (lecithin; intake per day: 12.4 mg) or with a control diet for 3 months. The two diets were isocaloric and differed only with respect to DHA, UMP, B-vitamins and phospholipids content. The amount of fat, carbohydrates and protein was the same between diets. During the 3 months of diet intervention, body weight was monitored as was food intake.

[0229]Results. Mice fed the enriched diet showed a 20% increase in body weight after 3 months compared to 14% for the control mice. Food intake was the same in the ω-3 PUFA+nucleoside+B-vitamins+phospholipids group (on average 3.02 gram per day) compared to control mice (on average 3.08 gram per day).

[0230]Conclusion. Alzheimer's disease mice showed an increase in body weight when f...

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Abstract

Composition comprising at least two components, more preferably at least three components, more preferably at least four components, selected from the group of (i) a nucleoside equivalent, (ii) an ω-3 polyunsaturated fatty acid selected from the group of DHA, DPA and EPA, (iii) a vitamin B, (iv) a phospholipid, (v) an antioxidant and (vi) a choline, with the proviso that at least component (i) or (iii) is present, for use in the prevention or treatment of frailty in a mammal, wherein frailty is determined by compliance with at least 2 criterions, preferably 3 criterions, selected from the group of muscle weakness, excessive feelings of exhaustion or fatigue, abnormally low physical activity, slow or unsteady gait, weight loss, and neurological dysfunction.

Description

FIELD OF THE INVENTION[0001]The invention relates to a combination of specific components for use in the prevention or treatment of frailty in a mammal, in particular for use in increasing one or more of body weight, body mass index, lean body weight, muscle mass, muscle strength, or muscle function, especially in an elderly human, more in particular in a human prone to or suffering from cognitive decline or dementia, in particular senile dementia, more in particular Alzheimer's disease.[0002]The invention also relates to the specific clinically relevant benefits that can be achieved in such persons, like improvement of stamina, an increased degree of activity during daytime and associated change in lifestyle. The invention also relates to a composition comprising said specific combination of components, either as a nutritional or pharmaceutical composition, which are suitable for achieving said effects in a frail mammal, especially in an elderly human, most in particular in a human...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/7072A61K31/20A61K31/14A61K31/7056A61K31/661A23L33/00A23L33/15
CPCA61K31/7072A61K31/7056A61K31/661A61K31/14A61K31/20A23V2002/00A61K31/202A61K31/355A61K31/375A61K31/4415A61K31/519A61K31/683A61K31/685A61K31/714A61K45/06A23L33/40A23L33/12A23L33/13A23L33/15C07H19/06C07H19/052A61K33/04A61K31/675A61P25/28A61K2300/00A23V2200/316A23V2200/322A23V2250/1882A23V2250/304A23V2250/704A23V2250/156A23V2250/1626A23V2250/1844A23V2250/1846A23V2250/1848A23V2250/185A23V2250/1852A23V2250/1868A23V2250/187A23V2250/5424A23V2250/7052A23V2250/7058A23V2250/706A23L33/14A61K31/44A61K31/4985A61K31/688A61K31/715A61K31/70A61K31/7068A23V2250/308
Inventor HAGEMAN, ROBERT JOHAN JOSEPHDE WILDE, MATTHEUS CORNELISGROENENDIJK, MARTINEKAMPHUIS, PATRICK JOSEPH GERARDUS HENDRIKUS
Owner NV NUTRICIA
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