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Therapeutic Cancer Vaccine Targeted to HAAH (Aspartyl-[Asparaginyl]-beta-Hydroxylase)

a technology of aspartyl-[asparaginyl]-beta-hydroxylase and cancer vaccine, which is applied in the field of therapeutic cancer vaccine targeted to haah (aspartyl-[asparaginyl]-beta-hydroxylase), can solve the problems of unmet clinical needs, unmet human life opportunity loss and health care cost, and cancer is one of the most devastating diseases

Inactive Publication Date: 2014-09-18
PANACEA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is about a cancer vaccine that targets human aspartyl-asparaginyl-β-hydroxylase (HAAH). The invention involves bacteriophage (bacteria) that expresses fragments of HAAH peptides or nano-particles that contain amino acid sequences native to HAAH. These bacteriophage or nano-particles can be used to stimulate the immune system of a patient and help treat cancer by targeting HAAH. The invention also includes nucleic acid constructs that encode the amino acid sequence of HAAH or bacteriophage lambda head decoration protein D. Overall, the invention provides methods for treating cancer by targeting HAAH and stimulating the immune system.

Problems solved by technology

Cancer is one of the most devastating diseases both in terms of human life opportunity loss and health care cost.
It also presents unmet clinical needs.
Currently available chemotherapies have limited efficacy and limited target patient population.
Moreover, essentially all cancer therapeutics have significant adverse side effects.
However, HAAH is well conserved and is also over expressed in placenta hence it is not sufficiently immunogenic in animals and it is certainly a self antigen in humans.

Method used

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  • Therapeutic Cancer Vaccine Targeted to HAAH (Aspartyl-[Asparaginyl]-beta-Hydroxylase)
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  • Therapeutic Cancer Vaccine Targeted to HAAH (Aspartyl-[Asparaginyl]-beta-Hydroxylase)

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Embodiment Construction

[0021]For simplicity and illustrative purposes, the principles of the present invention are described by referring to various exemplary embodiments thereof. Although the preferred embodiments of the invention are particularly disclosed herein, one of ordinary skill in the art will readily recognize that the same principles are equally applicable to, and can be implemented in other systems, and that any such variation would be within such modifications that do not part from the scope of the present invention. Before explaining the disclosed embodiments of the present invention in detail, it is to be understood that the invention is not limited in its application to the details of any particular arrangement shown, since the invention is capable of other embodiments. The terminology used herein is for the purpose of description and not of limitation. Further, although certain methods are described with reference to certain steps that are presented herein in certain order, in many insta...

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Abstract

The present invention encompasses a cancer vaccine therapy targeting Aspartyl-[Asparaginyl]-β-hydroxylase (HAAH). The present invention contemplate bacteriophage expressing HAAH peptide fragments and methods for using said bacteriophage in methods of treating cancer.

Description

BACKGROUND OF THE INVENTION[0001]Cancer is one of the most devastating diseases both in terms of human life opportunity loss and health care cost. It also presents unmet clinical needs. Currently available chemotherapies have limited efficacy and limited target patient population. Even the successful immunotherapies have shortcomings similar to chemotherapies. Moreover, essentially all cancer therapeutics have significant adverse side effects.[0002]Aspartyl-(Asparaginyl)-β-hydroxylase (HAAH) is over expressed in various malignant neoplasms, including hepatocellular and lung carcinomas. HAAH is a tumor specific antigen, which is specifically expressed on the surface of certain malignant cells. HAAH is a hydroxylation enzyme that modifies factors such as Notch that contribute to cancer etiology by causing cell proliferation, motility, and invasiveness. Neutralizing the enzyme or reducing its expression leads to normal phenotype(s) in cancer cells. Anti-HAAH antibodies (as well as siRN...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K39/00C12N9/02
CPCC12N9/0071A61K39/0011C12Y114/11016C07K2319/735A61K2039/5256A61K39/001154A61K39/4615A61K39/464454A61K39/4622
Inventor BISWAS, BISWAJITMERRIL, CARL R.GHANBARI, HOSSEIN A.
Owner PANACEA PHARMA