Glycation of l-lysine to lower blood glucose and treat complications of diabetes

a technology of llysine and lysine, which is applied in the field of llysine glycation to lower blood glucose and treat complications of diabetes, can solve the problems of accelerating diabetic complications and aging, the therapeutic use of l-lysine to lower blood glucose has not been accepted in traditional medical practice, and the beneficial effect of l-lysine glycation and urinary tract,

Inactive Publication Date: 2015-07-02
GOLDBERG JOEL STEVEN
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Problems solved by technology

However, because the teas are often prepared with boiling water it is unlikely that the active ingredient is a protein or any other class of compounds that may be heat labile.
Various amino acids in particular l-lysine are known to lower blood glucose when administered intravenously or orally, but therapeutic use of l-lysine to lower blood glucose has not been accepted in traditional medical practice.
Furthermore the prior art...

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  • Glycation of l-lysine to lower blood glucose and treat complications of diabetes

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[0010]Major mechanisms to lower blood glucose include diet, exercise and administration of insulin and oral hypoglycemic agents. The clinical utility of lowering blood glucose by glycating amino acids has not has not been reported. Even though the concentration ratio of chain glucose to cyclic glucose is very small, glycation in the form of glycated hemoglobin may be viewed as a homeostatic mechanism to lower the quantity of cyclic glucose by shifting the cyclic to chain glucose equilibrium in favor of a decrease in the cyclic form. When lysine glycation occurs, progression to the Amadori product is irreversible so one can view lysine glycation as a constant sink in the cyclic←→chain glucose equilibrium. (FIG. 1)

[0011]The formation of the Schiff base is nucleophilic addition at the carbonyl group of chain glucose with elimination of water to form the C═N bond. (FIG. 1) A carbonyl group is not present in cyclic glucose or in any of its isomers. All of the oxygen atoms in cyclic gluco...

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Abstract

Control of blood glucose is a fundamental goal in the treatment of diabetes mellitus. Glycation of l-lysine can lower blood glucose and advanced glycation end product (AGE) free adducts can be excreted in the urine. Lysine, an inexpensive amino acid, can be administered orally or parentally, and can be incorporated into a stereocomplex matrix as a time released preparation. In patients who suffer from diabetes and concomitant renal insufficiency who cannot clear sufficient quantities of AGE free adducts enantiomeric mixtures of lysine will lower blood glucose and AGEs since d-lysine has been shown to decrease protein glycation and lower hemoglobin Alc. This invention is not intended to replace insulin or oral hypoglycemic agents but is does offer patients a low cost and probably safe complementary therapy for the treatment of diabetes mellitus. In addition to the treatment of diabetes and its complications, this invention could lower AGE burden and slow or ameliorate some of the consequences of aging.

Description

CROSS-REFERENCES TO RELATED APPLICATIONS[0001]This application claims the benefits of U.S. Provisional Patent Application No. 61 / 923,073 filed Jan. 2, 2014 each of which is incorporated herein by reference in its entirely.FEDERALLY FUNDED RESEARCH[0002]Not applicableBACKGROUND OF THE INVENTION[0003]It is well known that decoctions (teas) prepared from the leaves of many plant species will lower blood glucose in diabetic animal models and in humans. (Deguchi & Miyazaki, 2010; Mudra, Ercan-Fang, Zhong, Fume, & Levitt, 2007; Umar, Moh'd, & Tanko, 2013) In Mexico approximately 269 plant species are used to control blood glucose in individuals afflicted with diabetes mellitus. (Hernandez-Galicia et al., 2002) In India leaf extracts of nine plants have been used by tribal communities to treat diabetes. (Arya, Abdullah, Haerian, & Mohd, 2012) Decoctions made from the leaves of Ficus carica (common fig) have been used where the plant is indigenous to lower blood glucose.[0004]A common mecha...

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Application Information

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IPC IPC(8): A61K31/198
CPCA61K31/198
Inventor GOLDBERG, JOEL STEVEN
Owner GOLDBERG JOEL STEVEN
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