Assessing renal structural alterations and outcomes

a technology of applied in the field of assessment of renal structural alterations and outcomes, can solve the problems of poor outcome, poor outcome, poor outcome, kidney failure, cardiac function, kidney failure, etc., and achieve the effect of increasing likelihood, increasing likelihood, and increasing the level of urinary cnp

Inactive Publication Date: 2015-10-15
MAYO FOUND FOR MEDICAL EDUCATION & RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008]This document provides methods and materials involved in assessing renal structural alterations (e.g., renal fibrosis, glomerular basement thickening, swollen podocytes, and foot processes effacement). For example, this document provides methods and materials for using the level of urinary CNP (e.g., a urinary to plasma CNP ratio) and/or the level of plasma CNP to determine whether or not a mammal is developing or is likely to develop renal structural alterations (e.g., renal fibrosis, glomerular basement thickening, mesangial matrix expansion, swollen podocytes, and foot processes effacement). Determining if a human patient is developing or is likely to develop renal structural alterations by assessing the level of urinary or plasma CNP (e.g., a urinary to plasma CNP ratio) can aid in the

Problems solved by technology

The poor outcome can be death, hospitalization, heart failure, myocardial infarction, worsening renal function, worsening cardiac function, or dialysis.
The poor outcome can be death, hospitalization, heart failure, myocardial in

Method used

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  • Assessing renal structural alterations and outcomes
  • Assessing renal structural alterations and outcomes
  • Assessing renal structural alterations and outcomes

Examples

Experimental program
Comparison scheme
Effect test

example 1

Use of Urinary CNP Excretion as Biomarker for Renal Fibrosis During Aging

Animals

[0056]Studies were performed in 2, 11, and 20 month old male Fischer rats (Harlan Laboratories, Inc., Madison, Wis., n=8-10 per age group, unless otherwise specified). The experimental study was performed in accordance with the Animal Welfare Act and with approval of the Mayo Clinic Institutional Animal Care and Use Committee.

Human Renal Biopsy Tissue

[0057]Human kidney tissue was obtained from core needle biopsy specimens from healthy living kidney donors at the time of kidney donation as described elsewhere (Rule et al., Ann. Intern. Med., 152:561-567 (2010)). A total of six paraffin-embedded renal biopsy specimens were examined in this study. The young group consisted of three female donors with mean age of 19 years old (age range 18 to 20 years old) and old group consisted of three 71 year old female donors.

24 Hours Urine Collection

[0058]Rats were placed in metabolic cages with free access to food and...

example 2

CNP is a Urinary Biomarker with Prognostic Value in Hospitalized Acute Decompensated Heart Failure (ADHF) Patients Independent of Glomerular Filtration Rate and NT-proBNP

Patient Population

[0075]Sixty ADHF (acute decompensated heart failure) patients were studied, and 20 healthy subjects were included as the control group. ADHF patients were prospectively identified and enrolled from a register of consecutive admissions. Inclusion criteria were a clinical diagnosis of systolic HF consistent with Framingham criteria (McKee et al., N Engl. J. Med., 285:1441-6 (1971)) for either new onset or established chronic HF, confirmed by reduced (<50%) left ventricular ejection fraction (LVEF) on echocardiography. In order that the study population may reflect the heterogeneity of normal clinical practice, the only exclusion criterion was incomplete or incorrect urine collection for adequate urinary biomarker analysis. Two ADHF patients were excluded for this reason, leaving a total of 58 consecu...

example 3

Plasma CNP-22 is an Endothelial Cell Biomarker that Predicts Mortality and Myocardial Infarction in the General Population

[0092]The following was performed to determine if plasma CNP-22 is an endothelial cell derived biomarker for predicting future mortality and myocardial infarction (MI) in the general population. Plasma CNP-22 was assessed in 1,841 subjects (mean age 62±11 years, 48% male) randomly selected from the general community of Olmsted County, MN, USA. Median follow-up for mortality and MI was 12 years. Over the 12 year follow-up period, elevated plasma CNP-22 (CNP-22>16 pg / mL) was significantly associated with mortality (unadjusted HR 1.41, 95% CI 1.12-1.79; P=0.004) and MI (unadjusted HR 1.60, 95% CI 1.19-2.16; P=0.002) (Table 7). After adjusting for traditional risk factors (e.g., age, gender, body mass index (BMI), cholesterol, serum creatinine, smoking, and presence of diabetes and hypertension), elevated plasma CNP-22 levels remained significantly associated with mo...

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Abstract

This document provides methods and materials involved in assessing renal structural alterations (e.g., renal fibrosis, glomerular basement thickening, mesangial matrix expansion, swollen podocytes, and foot processes effacement) as well as methods and materials involved in assessing outcomes. For example, methods and materials for using the level of urinary CNP (e.g., a urinary to plasma CNP ratio) to determine whether or not a mammal is developing renal structural alterations (e.g., renal fibrosis, glomerular basement thickening, mesangial matrix expansion, swollen podocytes, and foot processes effacement) as well as methods and materials for using the level of urinary CNP levels to identify patients having an increased likelihood of experiencing a poor outcome are provided.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of U.S. Provisional Application Ser. No. 61 / 580,139, filed Dec. 23, 2011. The disclosure of the prior application is considered part of (and is incorporated by reference in) the disclosure of this application.STATEMENT AS TO FEDERALLY SPONSORED RESEARCH[0002]This invention was made with government support under grants R01-HL36634 and P01-HL7661 awarded by National Institutes of Health. The government has certain rights in the invention.BACKGROUND[0003]1. Technical Field[0004]This document relates to methods and materials involved in assessing renal structural alterations (e.g., renal fibrosis) as well as methods and materials involved in assessing outcomes. For example, this document relates to methods and materials for using the level of urinary C-type natriuretic peptide (CNP) (e.g., a urinary to plasma CNP ratio) or the level of plasma CNP to determine whether or not a mammal is developing renal stru...

Claims

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Application Information

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IPC IPC(8): G01N33/68A61K38/22
CPCG01N33/6893A61K38/2242G01N2333/58G01N2800/324G01N2800/325G01N2800/347C07K14/58G01N2800/04G01N2800/042G01N2800/32G01N2800/56A61K45/06G01N2800/52
Inventor SANGARALINGHAM, SASANTHA J.BURNETT, JR., JOHN C.CATALIOTTI, ALESSANDROHEUBLEIN, DENISE M.
Owner MAYO FOUND FOR MEDICAL EDUCATION & RES
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