HIV Antigens and Antibodies

a technology of antigens and antibodies, applied in the field of hiv antigens and antibodies, can solve the problems of inability to cure hiv-1 infection, inability to effectively prevent infection, and limited current treatment options for hiv-infected individuals, so as to reduce hiv-1 transmission and disease progression.
US20160002319A1Inactive Publication Date: 2016-01-07THERABIOL
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
THERABIOL
Publication Date
2016-01-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a method for reducing the occurance and / or severity of viral infections. The method embodies procedures for expanding HIV from the blood of HIV antibody negative donors and deriving a non-infectious virus particle product that is antigenic. The procedures for deriving the antigenic, non-infectious virus particle product are optimally designed to maintain the integrity of the envelope proteins while maximizing the depletion of capsid proteins and RNA. The resulting virus particle product, when introduced into humans or non-human animals, enables the production of antibodies that target the natural envelope macromolecular structure that is required for infectivity. The present invention can be applied to producing virus stocks from the blood of HIV-seronegative donors, for deriving non-infectious virus particles that retain intact envelope proteins, for producing anti-viral antibodies, and for administering anti-virus antibodies to patients.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of U.S. Provisional Application No. 61 / 770,974, filed Feb. 28, 2013. The entire teachings of these applications are incorporated herein by reference for all purposes.BACKGROUND OF THE INVENTION

[0002] 1. Field of the Invention

[0003] The present invention relates to novel HIV-1 antigenic compositions that can be used to produce antibodies that neutralize multiple strains of HIV-1, the use of such antigenic compositions to induce an immune response in a subject, and the use of such antibodies in prophylactic and therapeutic methods.

[0004] 2. Description of the Related Art

[0005] Acquired immune deficiency syndrome (AIDS) is a life-threatening clinical condition caused by infection with the Human Immunodeficiency Virus 1 (HIV-1) (Killian M S, Levy J A, European Journal of Immunology 2011, 41: 3401-3411). AIDS was first described in a set of unusual clinical cases the early 1980s and its causative agent was ident...

Claims

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