Generation of ctl lines with specificity against multiple tumor antigens or multiple viruses

a technology of ctl lines and tumor antigens, applied in the field of cell biology, immunology, molecular biology, medicine, can solve the problems of generating resistant variants, substantial toxicities, and viral infections accounting for substantial morbidity and mortality in immunocompromised hosts, and achieve the effect of reducing cell death and proliferating
US20160362658A1Active Publication Date: 2016-12-15BAYLOR COLLEGE OF MEDICINE +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
BAYLOR COLLEGE OF MEDICINE
Publication Date
2016-12-15

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Abstract

The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and / or that employ a particular bioreactor having a gas permeable membrane.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation application of U.S. patent application Ser. No. 12 / 862,409, filed Aug. 24, 2010, which claims priority to U.S. Provisional Patent Application Ser. No. 61 / 236,261, filed Aug. 24, 2009, both of which applications are incorporated by reference herein in their entirety.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

[0002] This invention was made with government support under P50 CA126752 awarded by NIH-NCI. The government has certain rights in the invention.TECHNICAL FIELD

[0003] The present invention generally concerns the fields of cell biology, immunology, molecular biology, and medicine. In particular embodiments, the invention generally concerns immunotherapy for cancer.BACKGROUND OF THE INVENTION

[0004] Multivirus-Specific T Cells for Prevention and / or Treatment of Viral Infections in the Immunocompromised Host

[0005] Viral infections account for substantial morbidity and mortality in the immu...

Claims

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