Modulation of oxidative stress, inflammation, and impaired insulin sensitivity with grape seed extract

Abstract

Method for modulating oxidative stress, inflammation, and impaired insulin sensitivity in a subject by using a grape seed extract, the method being useful in modulating post-prandial oxidative stress, inflammation, and impaired insulin sensitivity in patients suffering from Metabolic Syndrome (MetS). The method comprising administering a therapeutically effective amount of a grape seed extract and a pharmaceutically acceptable excipient. The grape seed extract is a polyphenolic extract comprising proanthocyanidins and anthocyanidins.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]The present invention is a divisional of U.S. patent application Ser. No. 14 / 391,893, filed Oct. 10, 2014, which is a 371 national phase application of PCT / US2013 / 035944, filed Apr. 10, 2013, which claims the benefit of the following U.S. Provisional Patent Application No. 61 / 622,339, filed Apr. 10, 2012 and the following U.S. Non-provisional patent application Ser. No. 13 / 841,673, filed Mar. 15, 2013. The contents of these applications are incorporated herein by reference in their entireties.FIELD OF THE INVENTION[0002]The invention relates to the use of grape seed extracts in modulating oxidative stress, inflammation, and impaired insulin sensitivity in a patient, particular a patient suffering from metabolic syndrome.BACKGROUND OF THE INVENTION[0003]Metabolic syndrome (Met.S) is a growing medical problem in industrialized countries and is diagnosed when three of the following factors are present: abdominal obesity, elevated serum trigl...

AI Technical Summary

Benefits of technology

The patent describes a method for using a grape seed extract to treat and prevent conditions related to metabolic syndrome, including oxidative stress, inflammation, impaired insulin sensitivity, and type II diabetes. The grape seed extract can be administered as a pharmaceutical composition or as a food supplement. The technical effect of this invention is to provide an effective treatment for metabolic syndrome and its related conditions using a natural and safe ingredient.

Problems solved by technology

Oxidative stress impairs glucose uptake in muscle and fat and decreases insulin secretion from β cells of the pancreas, resulting in prolonged hyperglycemia, increased glycation endproducts and endothelial dysfunction, all of which contribute to the development of atherosclerosis.

Since insulin resistance presents before the development of diabetes, early intervention strategies designed to reduce insulin resistance and improve glucose control could ameliorate unfavorable effects on blood vessels and risk for micro- and macro-vascular disease.

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