Modulation of oxidative stress, inflammation, and impaired insulin sensitivity with grape seed extract

a technology of oxidative stress and inflammation, which is applied in the direction of medical preparations, plant ingredients, plant/algae/fungi/lichens ingredients, etc., can solve the problems of prolonging hyperglycemia, reducing the risk of micro- and macrovascular disease, and ameliorating unfavorable effects on blood vessels

Inactive Publication Date: 2017-06-15
RGT UNIV OF CALIFORNIA +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Oxidative stress impairs glucose uptake in muscle and fat and decreases insulin secretion from β cells of the pancreas, resulting in prolonged hyperglycemia, increased glycation endproducts and endothelial dysfunction, all of which contribute to the development of atherosclerosis.
Since insulin resistance presents before the development of diabetes, early intervention strategies designed to reduce insulin resistance and improve glucose control could ameliorate unfavorable effects on blood vessels and risk for micro- and macro-vascular disease.

Method used

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  • Modulation of oxidative stress, inflammation, and impaired insulin sensitivity with grape seed extract
  • Modulation of oxidative stress, inflammation, and impaired insulin sensitivity with grape seed extract
  • Modulation of oxidative stress, inflammation, and impaired insulin sensitivity with grape seed extract

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Human Clinical Trial

[0065]The Human Subjects Research Committee of the University of California, Davis, approved the study. All participants signed a written informed consent form before any study-related procedures were performed; verbal consent was given during the telephone interview prior to answering study screening questions.

Grape Seed Extract

[0066]The GSE (GSE, MegaNatural®-Gold)) used in the study was obtained from Polyphenolic Inc, Madera, Calif. Total phenolic level is 94.3 gallic acid equivalents (wt / wt) as assessed by the Folin & Ciocalteu method. The moisture content is 4.1%. The detailed polyphenolic composition as assessed using LC-MS / MS is given in Table 1.

TABLE 1Polyphenolic composition of the Grape Seed Extract (GSE)*Name of the compound% compositionTotal Gallic Acid5.7Catechin6.7Epicatechin4.8Dimer B34.4Polymer46.1*Meganatural Gold, Polyphenolic, Inc, Madera, CA

Subjects

[0067]Twelve subjects (n=12, 7 females and 5 males) identified with Met S according to the NCEP ...

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Abstract

Method for modulating oxidative stress, inflammation, and impaired insulin sensitivity in a subject by using a grape seed extract, the method being useful in modulating post-prandial oxidative stress, inflammation, and impaired insulin sensitivity in patients suffering from Metabolic Syndrome (MetS). The method comprising administering a therapeutically effective amount of a grape seed extract and a pharmaceutically acceptable excipient. The grape seed extract is a polyphenolic extract comprising proanthocyanidins and anthocyanidins.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]The present invention is a divisional of U.S. patent application Ser. No. 14 / 391,893, filed Oct. 10, 2014, which is a 371 national phase application of PCT / US2013 / 035944, filed Apr. 10, 2013, which claims the benefit of the following U.S. Provisional Patent Application No. 61 / 622,339, filed Apr. 10, 2012 and the following U.S. Non-provisional patent application Ser. No. 13 / 841,673, filed Mar. 15, 2013. The contents of these applications are incorporated herein by reference in their entireties.FIELD OF THE INVENTION[0002]The invention relates to the use of grape seed extracts in modulating oxidative stress, inflammation, and impaired insulin sensitivity in a patient, particular a patient suffering from metabolic syndrome.BACKGROUND OF THE INVENTION[0003]Metabolic syndrome (Met.S) is a growing medical problem in industrialized countries and is diagnosed when three of the following factors are present: abdominal obesity, elevated serum trigl...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/87A61K31/192A61K31/353
CPCA61K36/87A61K31/192A61K31/353A61K2300/00
Inventor KAPPAGODA, CHULANI T.BURTON-FREEMAN, BRITTEDIRISINGHE, INDIKA
Owner RGT UNIV OF CALIFORNIA
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