Fluorinated 2-amino-4-(substituted amino)phenyl carbamate derivatives

a technology of phenyl carbamate and substituted amino, which is applied in the direction of heterocyclic compound active ingredients, drug compositions, organic chemistry, etc., can solve the problems of depression and sexual function, memory decline or worsening, depression and other lifestyle limitations, and many patients are not adequately treated with the current available options, so as to achieve the effect of treating or preventing
US20170355679A1Inactive Publication Date: 2017-12-14SCIFLUOR LIFE SCI
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
SCIFLUOR LIFE SCI
Publication Date
2017-12-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The application relates to 2-amino-4-(substituted amino)phenyl carbamate derivatives, or pharmaceutically acceptable salts or solvates thereof, as KCNQ2 / 3 potassium channel modulators, and methods of their uses.
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Description

RELATED APPLICATION

[0001] This application claims priority to, and the benefit of, U.S. Ser. No. 62 / 348,481, filed on Jun. 10, 2016, the entire contents of which are incorporated herein by reference.BACKGROUND

[0002] Epilepsy is one of the most common chronic neurological disorders, and affects approximately 50 million people worldwide. Epilepsy patients have significantly increased morbidity, including closed head injury, fractures, burns, dental injury and soft tissue injury. Decline in or worsening of memory, cognition, depression and sexual function and other lifestyle limitations occur frequently in epilepsy patients. Epilepsy patients also have an increased risk of mortality compared to the general population.

[0003] Although various pharmacologic agents are approved to treat epilepsy, many patients are not adequately treated with the currently available options. It is estimated that nearly a third of patients with epilepsy have either intractable or uncontrolled seizures or signif...

Claims

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