Block co-poly(metal organic nanostructures) (bcpmons) and uses thereof

a technology of metal organic nanostructures and co-polymers, which is applied in the field of block copoly (metal organic nanostructures) (bcpmons), can solve the problems of more difficult to achieve in synthetic polymers, and achieve the effect of low molecular weigh

Active Publication Date: 2018-09-13
MASSACHUSETTS INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0135]A “therapeutically effective amount” of a compound described herein is an amount sufficient to provide a therapeutic benefit in the treatment of a condition or to delay or minimize one or more symptoms associated with the condition. A therapeutically effective amount of a compound means an amount of therapeutic agent, alone or in combination with other therapies, which provides a therapeutic benefit in the treatment of the condition. The term “therapeutically effective amount” can encompass an amount that improves overall therapy, reduces or avoids symptoms, signs, or causes of the condition, and / or enhances the therapeutic efficacy of another therapeutic agent.

Problems solved by technology

Such structural hierarchy is common in biomaterials, but is often more difficult to achieve in synthetic polymers.

Method used

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  • Block co-poly(metal organic nanostructures) (bcpmons) and uses thereof
  • Block co-poly(metal organic nanostructures) (bcpmons) and uses thereof
  • Block co-poly(metal organic nanostructures) (bcpmons) and uses thereof

Examples

Experimental program
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Effect test

example 1

on and Characterization of BCPMONs of Formula (A) or (B)

[0746]For the realization of exemplary BCPMONs, poly(methyl methacrylate)-block-poly(n-butyl acrylate) (PMMA-b-PBA, or PMMA-PBA) bearing a pyridyl ligand at the chain end was used. PMMA-PBA is known to phase separate in the bulk state as well as in suitable solvents.56-57 The ligands of choice are shown in FIG. 1B. In the presence of Pd ions, these ligands form PdxLy complexes with different geometries: ligand L1 forms a square planar ML4 complex (this ligand may serve as a control for comparison to BCPMONs), while ligands L2 and L3 are structural isomers of meta- and para-bispyridine that assemble into M2L4 paddlewheel and M12L24 Fujita sphere MONs, respectively. Schematics for these complexes are shown in FIG. 1C.

BCP Synthesis

[0747]The BCPs were synthesized via atom transfer radical polymerization (ATRP), followed by post-polymerization functionalization (FIG. 2A). Using Ethyl a-bromophenylacetate (EBPA) as the initiator, the...

example 2

on and Characterization of BCPMONs of Formula (C)

[0861]Herein, the synthesis of uniform oligomeric polyMOF ligands with alkyne end groups via an iterative exponential growth (IEG) strategy is reported. These ligands were used to prepare a diblock copolymer via copper-catalyzed azide-alkyne cycloaddition “click” chemistry with azide-terminated polystyrene (PS). In the presence of Zn ions, this novel block copolymer forms a BCPMON comprised of crystalline polyMOF domains embedded in an amorphous PS matrix.

[0862]Block copolymer (BCP) assemblies and metal-organic frameworks (MOFs) are two classes of self-assembled matter with vastly different structures and properties. The former may be derived from covalently linked, flexible polymer chains that may undergo phase separation on length scales typically ranging from ˜10-100 nm.1,2 BCPs may be useful for separations, micropatterning, battery, and electronics technologies.1,2 On the other hand, MOFs are crystalline networks, optionally with...

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Abstract

The present disclosure provides (block co-polymer)-(metal organic framework) conjugates (BCPMOFs), such as (block co-polymer)-(metal organic nanostructure) conjugates (BCPMONs), and thermoplastic elastomers, gels, and compositions thereof. Exemplary BCPMONs include (block co-polymer)-(metal organic cage) conjugates (BCPMOCs), (block co-polymer)-(metal organic paddlewheel) conjugates, and (block co-polymer)-(metal organic square) conjugates, such as BCPMONs of Formula (A), (B), or (C). Also described herein are macromonomers for preparing the BCPMONs; thermoplastic elastomers, gels, and compositions involving the BCPMONs; methods of preparing the BCPMONs, thermoplastic elastomers, gels, and compositions; and methods of using the BCPMONs, thermoplastic elastomers, gels, and compositions.

Description

RELATED APPLICATION[0001]The present application claims priority under 35 U.S.C. §119(e) to U.S. provisional application, U.S. Ser. No. 62 / 367,630, filed Jul. 27, 2016, which is incorporated herein by reference.GOVERNMENT SUPPORT[0002]This invention was made with Government support under Grant Nos. CHE-1334703 and CHE-1351646 awarded by the National Science Foundation. The Government has certain rights in the invention.BACKGROUND OF THE DISCLOSURE[0003]Coordination-directed self-assembly of metal ions and organic ligands is a powerful approach for the construction of two- and three-dimensional molecular architectures.1-10 Examples of such structures range from discrete metal organic cycles and metal organic cages / polyhedra (MOCs / MOPs)11-27 to infinite metal organic frameworks (MOFs)28-31. By rational design of the ligands and proper choice of the metal ions, these materials can feature well-defined sizes, shapes, geometries, and porosity, which enable applications in selective encap...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C08J3/075C08F293/00A61K47/32
CPCC08J3/075A61K47/32C08F293/005C07F15/00C07F15/0066C07F3/06C08G83/001C08G83/008
Inventor JOHNSON, JEREMIAH A.WANG, YUFENGMACLEOD, MICHELLE
Owner MASSACHUSETTS INST OF TECH
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