Coenzyme Q10 Aerosol

a technology of coenzyme q10 and aerosol, which is applied in the direction of dispersed delivery, anti-noxious agents, drug compositions, etc., can solve the problems of inability to mill, difficulty in formulating, etc., and achieves high coq10 concentration, high and sustained systemic concentration, and high lipophilic

Inactive Publication Date: 2020-06-25
UNM RAINFOREST INNOVATIONS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0003]By directly targeting the lung, a high concentration of CoQ10 can be achieved for local therapy. Additionally, absorption via the pulmonary route can provide a higher and sustained systemic concentration with one or more doses. CoQ10 is highly lipophilic and can therefore have a long residence time in the lung epithelium to provide an extended local therapeutic time.

Problems solved by technology

Coenzyme Q10 has a melting point around 50° C. and this makes it difficult to formulate since it is a waxy material; for example, it cannot be milled using conventional methods.

Method used

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  • Coenzyme Q10 Aerosol
  • Coenzyme Q10 Aerosol

Examples

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[0058]Method

[0059]A mixture of surfactants (e.g., Tween80 and Capryo190) is made and vortexed for about 2 minutes.

[0060]The triglyceride of coconut oil was weighed in a glass vessel. It was then allowed to stand for one hour in a water bath with 37° C. along with the CoQ10, after which it was cooled down and the surfactant mixture was added. This composition was then mixed with the vortexer for about 30 seconds. After which, the composition was allowed to stand until the next day. Water was then added and it was mixed for about 1 min.

[0061]In yet another embodiment, the present provides a method for making and administering an aerosol formulation containing a desired amount of CoQ10 that is particularly useful for creating aerosol treatments having respirable compositions. In this embodiment, the emulsion is isotonic and may be made from an oil in water mixture as well as other isotonic mixtures. In a preferred embodiment, an isotonic agent is used such as dextrose, glycerin, potass...

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Abstract

The present invention provides a formulation of Coenzyme Q10 that can be re-dispersed from a stable dry powder to formulation to yield a nanodispersion that can be readily aerosolized for inhalation.

Description

RELATED APPLICATIONS[0001]This application is a continuation of U.S. Ser. No. 15 / 738512 filed on Dec. 20, 2017, which is a U.S. National Phase of PCT / US2016 / 039173 filed on Jun. 24, 2016, which claims the benefit of U.S. Provisional Application No. 62 / 185312 filed Jun. 26, 2015 and herein incorporated by reference.BACKGROUND OF THE INVENTION[0002]Coenzyme Q10 has a melting point around 50° C. and this makes it difficult to formulate since it is a waxy material; for example, it cannot be milled using conventional methods. Additionally, CoQ10 is degraded by heat and exposure to UV light. CoQ10 is poorly absorbed via the oral route, additionally CoQ10 has a short half-life in the body when administered via the intravenous route, this is because it is ubiquitous to the body and so is easily eliminated.BRIEF SUMMARY OF THE INVENTION[0003]By directly targeting the lung, a high concentration of CoQ10 can be achieved for local therapy. Additionally, absorption via the pulmonary route can pr...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/00A61K47/26A61K47/14A61K31/122
CPCA61K47/14A61K9/0078A61K47/26A61K31/122A61P39/06A61P43/00
Inventor MCCONVILLE, JASON THOMASCARVALHO, THIAGO CARDOSOSCHÖNHOFF, KRISTINA
Owner UNM RAINFOREST INNOVATIONS
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