Micropenetrator device for penetrating a biological barrier
a technology of micro-penetration and biological barrier, which is applied in the field of micro-penetration device for penetrating biological barrier, can solve the problems of inability to achieve reliable and reproducible penetration, create structures that are inherently difficult to integrate with existing patches and other formulations, and extreme difficulty in getting sharp enough tips, etc., to achieve low pain, greater reproducibility, and low skill
Inactive Publication Date: 2020-07-23
XOBADERM
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AI Technical Summary
Benefits of technology
The present invention provides a low-cost, minimally invasive device for treatment of biological materials like skin. It can deliver pharmaceutical, cosmetic, or immunological activities through biological barriers like the stratum corneum, epidermis, or dermis. This device is a better alternative to conventional needles as it causes less pain and can be used with greater reproducibility. It can also be used on wounds or scars where the skin is not intact.
Problems solved by technology
Microneedles have been used in research for transdermal delivery of drugs and vaccines, but there have been limitations due to complexity of manufacture and scale up, as well as the “bed of nails” effect creating difficulty in attaining reliable and reproducible penetration.
Also the manufacturing method creates structures that are inherently difficult to integrate with existing patch and other formulations.
There are several inherent problems with this technique, however, including the extreme difficulty of getting sharp enough tips that simultaneously are strong enough to withstand shear forces so as not to break in the skin.
Method used
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Embodiment Construction
[0150]Referring to FIG. 1a a device according to an exemplary embodiment of the present invention is presented. The device 2 is presented prior to activation and contact with a biological barrier 5. The device 2 comprises a flexible substrate 3 having a biological barrier contact surface 4. In the embodiment presented a supplementary layer 6 is provided on the second opposing side 8 of the flexible substrate. Presented in this embodiment for clarity purposes are two micropenetrator arrangements 10 each comprising a head 12 and first and second projections 14, 16. The projections extend to a tip 18 and in the form presented are sharpened to a point through cutting the respective projections at an angle non-perpendicular to the longitudinal length of the respective projections. The head 12 comprises an abutment surface 20 which may abut the second side 8 of the flexible substrate 3. In the embodiment presented, due to the provision of the supplementary layer 6 the head 12 is encapsula...
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A device that may be placed on a biological barrier can be used to perforate the biological barrier for a variety of purposes such as cosmetic, scar treatment or for the delivery of active agents. A flexible substrate has a first side and a second opposing side and a plurality of micropenetrator arrangements each comprising a head and a first and second projection, for penetrating a biological barrier, extending from the head. The first and second projection at least partially extend through the flexible substrate towards the first side. The head comprises an elongate arm for spacing apart the first and second projections. A force is applied to the second side causing flexing of the flexible substrate and pushing the projections into communication with a biological barrier.
Description
CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a Continuation of U.S. Ser. No. 15 / 528,821, filed on May 23, 2017, which is the U.S. national stage of PCT / GB2015 / 053592 filed Nov. 25, 2015 which claims priority to GB1420946.4 filed Nov. 25, 2014 and GB1517832.0 filed Oct. 8, 2015. The entirety of each is incorporated herein.FIELD OF THE INVENTION[0002]The present invention relates to a device that may be placed on a biological barrier, such as the stratum corneum, and then be used to perforate the biological barrier for a variety of purposes such as cosmetic, scar treatment or for the delivery of active agents for systemic or local treatment or vaccination.BACKGROUND OF THE INVENTION[0003]Microneedles have been an interesting research topic for many years in the field of transdermal drug delivery and also in aesthetic dermatology. It has been in this aesthetic field where the first microneedle products have appeared. Treatment using devices such as a barrel having m...
Claims
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IPC IPC(8): A61M37/00A61B17/20
CPCA61B17/205A61M2037/0023A61M37/0015A61B2017/00747A61M2037/0053A61M2037/0046A61M2037/003A61M2037/0061
Inventor KIRBY, ANDREW JAMES
Owner XOBADERM