Reinforced bioreactor component structure system for cell cultivation

a bioreactor and component structure technology, applied in the field of cell culture cell culture bags, can solve the problems of requiring a large space, unable to handle multiple patient samples at the same time, and cell culture was stand alone, so as to prevent crimping of the tube structure

Inactive Publication Date: 2021-01-21
GE HEALTHCARE BIO SCI CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0016]The present invention includes aspects relating to an improved bioprocess bag and related structures, including reinforced and improved tube features. In one aspect, the invention relates to an improved bioprocess bag including a bag wall defining an enclosed volume for holding biomaterials, the bag wall comprising at least one inlet port and at least one outlet port; and a tube structure comprising a first opened-end proximate the bag wall and a second distal end, the tube extending into the enclosed volume, and the tube structure comprising a reinforced portion proximate the first opened-end. The reinforced section may include a pattern of sections that are raised relative to the tube outer surface, and the raised sections contacting each other when the tube structure is bent. The contact may prevent crimping of the tube structure during shipping, setup or operation.

Problems solved by technology

Earlier systems for cell culture were stand alone, required large space and could not handle multiple patient samples at same time.
Procedures for cell culturing for cell therapy involve a lot of human intervention, which may contaminate cell cultures and damage cell growth, especially small size cell cultures.

Method used

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  • Reinforced bioreactor component structure system for cell cultivation
  • Reinforced bioreactor component structure system for cell cultivation
  • Reinforced bioreactor component structure system for cell cultivation

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Embodiment Construction

[0027]The present inventors have found that several of the internal structures of a bioreactor or fermenter bag are susceptible to damage or perceived damage as a result of sterilization and packaging, and further damage to these elements can occur during shipping, setup, or use. The sterilization of the bag with gamma irradiation can in some cases exacerbate the problem by fusing adjacent pieces of material or freezing the material into bent shape. With respect to parts that are internal to the bag, these problems are sometimes compounded by the inability to inspect internal portions of the bag given the need to maintain sterility and not compromise the bag structure. The perception of damage to an internal part may result in the entire bag being deemed unsuitable for use. The tube structure maybe adapted to accept a probe, such as a thermocouple, or a sparging wand. Alternatively, or in addition, the tube structure may be adapted for introducing or withdrawing material from the bi...

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Abstract

The present invention involves a reinforced tubing structure that is particularly useful for reinforcing tubing that is present inside disposable bioreactor bags, including for example thermowell tubing.

Description

FIELD OF THE INVENTION[0001]The present invention relates to a novel bioprocess bag for cell cultivation having reinforced internal structures. More specifically, the invention relates to an improved bioprocess bag and related structures, including reinforced and improved tube features.BACKGROUND OF THE INVENTION[0002]Cell therapy is a new but rapidly expanding field in biotechnology which involves the administration of autologous or allogeneic cells that carry out a therapeutic effect in vivo. Cell therapy involves a number of mandatory stages from cell collection to cell injection into a patient. Cell culturing for cell therapy is carried out in clean room environment. Cell culturing and clean rooms has many mandatory regulations like particle size and count in clean room, number of patient samples handled at a time, and number of instruments per suite, as well as a requirement for a sterile environment etc.[0003]Earlier systems for cell culture were stand alone, required large sp...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): B01L3/00B01L7/00C12M1/00C12M1/34
CPCB01L3/561B01L3/505B01L7/00C12M23/14C12M23/26C12M41/12B01L2300/0832B01L2300/0609B01L2300/0627B01L2200/0684B01L2400/0475B01L2300/18C12M29/00C12M23/28C12M37/00B01L2200/147B01L2300/123
Inventor TUOHEY, COLINSTANKOWSKI, RALPH
Owner GE HEALTHCARE BIO SCI CORP
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