Creatine, its derivatives, compositions and methods of use thereof

Abstract

The application describes creatine or its derivatives, compositions comprising the same, and uses thereof for topical or systemic administration to treat pain, itch, or eczema, or inflammation associated with a cosmetic or medical condition, disorder or disease in a human subject, wherein the inflammation causes the pain, itch, or eczema. In addition, the application describes clinical use of these compounds and compositions which can reduce or eliminate erythema, edema and tissue distortions associated with inflammation.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority under 35 U.S.C. §119 to U.S. Provisional Patent Application No. 63 / 169,584, filed on April 1, 2021, and U.S Provisional Patent Application No. 63 / 241,130, filed on Sep. 7, 2021, the disclosures of which are herein incorporated by reference in their entireties.FIELD OF THE INVENTION[0002]The application describes creatine or its derivatives, compositions comprising the same, and uses thereof for topical or systemic administration to treat pain, itch, or eczema, or inflammation associated with a cosmetic or medical condition, disorder or disease in a human subject. In addition, the application describes clinical use of these compounds and compositions which can reduce or eliminate erythema, edema and tissue distortions associated with inflammation.BACKGROUND OF THE INVENTION[0003]Creatine is thought to improve strength, increase lean muscle mass, and help the muscles recover more quickly during exercise. Thi...

AI Technical Summary

Benefits of technology

[0107]A female subject, age 68, with worsening osteoarthritis of both knees, who had been advised to have surgical knee replacement, sought advice on possible alternative treatments. She was provided with the following formulations for topical applications: Formulation A:

[0109]Subject reported that the formulation A and formulation B were equally effective in providing pain relief, of estimated 80%, within 3-8 minutes after application to the knees and lasting for 4-5 hours. Pain relief has been sufficient for her to postpone consideration of knee replacement until the COVID-19 pandemic is subdued.

[0110]A female subject, age 62, with aggravating lower back pain of 2-3 years duration, was provided 8 ounces of Formulation A (Example 4) to be applied to the lower back in late afternoon when her lower back pain intensified from mild to substantial. Pain subsided completely within 3-4 minutes, not returning until early afternoon the next day, beginning as mild and worsening during the afternoon hours.

[0111]Subject w

Problems solved by technology

However, none of the prior art described the use of creatine derivatives of the current inve