41results about How to "Not prone to problems such as peeling off" patented technology

The invention relates to a multi-channel chip device for AIDS diagnosis using PDMS as a substrate, belonging to the field of analysis and testing. Using cheap and easy-to-process polydimethylsiloxane (PDMS) to make the substrate of the microfluidic chip for AIDS diagnosis has a series of problems. The gist of this case is that the substrate is selected from PDMS with an original ecological surface, and the hinged fixture with a micro-ultrasonic transducer is manually fastened and positioned in the vicinity of the sample liquid flow terminal of the microfluidic chip, so as to Ultrasound induces the driving force based on the difference in interfacial tension, and at the same time, it is coupled with the driving force of the micropump to drive the sample liquid to flow in the direction of the terminal. The pipe of the chip is filled with micron-sized silica particles. Its functions include supporting the inner wall of the pipeline, compensating the original hydrophobic pipeline with a collection of hydrophilic micro-channels, and squeezing and covering the inner wall of the pipeline to reduce the chance of biomacromolecules in contact with the inner wall.

The present invention relates to a recyclable cholera diagnosis apparatus used for driving and having an easily disassemble member, and belongs to the field of analytical testing. According to the present invention, the use of inexpensive and easily-processed polydimethylsiloxane (PDMS) to produce the substrate of a microfluidic chip for cholera diagnosis has a series of technical problems. The technical scheme of the present invention is characterized in that the substrate selects PDMS having an original ecological surface, an elastic clamper provided with a micro-ultrasonic wave transducer arranged on the clamping arm is positioned on the sample liquid flow terminal position of the microfluidic chip in an elastic snapping manner, ultrasonic waves induce to form driving force based on the interfacial tension difference, and through the coupled operation with the driving force of a micro pump, the sample liquid flow is synergistically driven to flow to the terminal direction; and the pipeline of the chip is filled with a micro-scale silica particle filler, and the micro-scale silica particle filler is used for supporting the inner wall of the pipeline, compensating the original hydrophobic pipeline with a hydrophilic micro-channel set, and extruding and covering the inner wall surface of the pipeline so as to reduce the opportunity of the contact between biological macromolecules and the inner wall surface.

The present invention relates to a subtype swine influenza detection device using an easy-to-disassembly dual-drive coupled mode, and belongs to the field of analysis and testing. When inexpensive andhighly processable polydimethylsiloxane, namely PDMS is used for making a substrate of a microfluidic chip for diagnosis of subtype swine influenza, a series of problems are needed to be solved. Themain point of the subtype swine influenza diagnosis microfluidic device is that the material of the substrate is the PDMS with an original ecological surface, and the pipe of the chip is filled with doped micron-sized titanium dioxide particles; the titanium dioxide particles have super-hydrophilic surface induced in advance by visible light irradiation; collection of super-hydrophilic channels among the particles of a titanium dioxide particle filler compensates and surpasses an original strong hydrophobic pipe, a constant and super-hydrophilic modification effect can be achieved, and by a small-power ultrasonic drive and micro-pump drive dual-drive coupled operation mode, a sample flow is guided to flow along the pipe of the chip to terminal direction.

The invention relates to a microfluidic chip device for subtype swine influenza detection comprising a hydrophobic substrate, which belongs to the field of analysis and testing. There are several difficulties in using cheap and easy-to-process polydimethylsiloxane (PDMS) to fabricate the substrate of the microfluidic chip for subtype swine influenza diagnosis. The main point of this case is that PDMS with an original ecological surface is selected as the substrate, and the hinge-type fixture with a micro-ultrasonic transducer is manually fastened and positioned at the terminal position of the sample liquid flow of the chip, and an interface-based surface is formed by ultrasonic induction. The driving force of the tension difference, coupled with the driving force of the micropump, synergistically drives the sample liquid to flow in the direction of the terminal. The pipe of the chip is filled with micron-sized silica particle fillers. The functions of the filler include supporting The inner wall of the pipeline, and the original hydrophobic pipeline is compensated by a collection of hydrophilic micro-channels, and the inner wall of the pipeline is squeezed and covered to reduce the chance of biomacromolecules in contact with the inner wall.

The invention relates to a multi-channel microfluidic chip device for AIDS diagnosis involving a hydrophobic substrate, belonging to the field of analysis and testing. There are several difficulties in making the substrate of the microfluidic chip for AIDS diagnosis with cheap and easy-to-process polydimethylsiloxane (PDMS). The main point of this case is that the PDMS with the original ecological surface is selected as the substrate, and the hinged fixture with the micro-ultrasonic transducer is manually fastened and positioned at the terminal position of the sample liquid flow of the microfluidic chip. The driving force based on the difference in interfacial tension is formed, and at the same time, it is coupled with the driving force of the micropump to jointly drive the sample liquid to flow in the direction of the terminal. The pipeline of the chip is filled with micron-sized silica particle fillers. The functions include supporting the inner wall of the pipeline, compensating the originally hydrophobic pipeline with a collection of hydrophilic micro-channels, and squeezing and covering the inner wall of the pipeline so as to reduce the chance of biomacromolecules contacting the inner wall.

The invention relates to a microfluidic chip device for subtype swine influenza detection using a strong hydrophobic substrate, belonging to the field of analysis and testing. There are actually a series of difficulties in using cheap and easy-to-process polydimethylsiloxane (PDMS) to fabricate the substrate of the microfluidic chip for subtype swine influenza diagnosis. The main point of this case is that the PDMS with the original ecological surface is selected as the substrate, and the hinged fixture with the micro-ultrasonic transducer is manually fastened and positioned at the terminal position of the sample liquid flow of the chip, and the interface is formed by ultrasonic induction. The driving force of the tension difference, coupled with the driving force of the micropump, synergistically drives the sample liquid to flow in the direction of the terminal. The pipe of the chip is filled with micron-sized silica particle fillers. The functions of the filler include supporting The inner wall of the pipeline, and a collection of hydrophilic micro-channels are used to compensate the original hydrophobic pipeline, and the inner wall of the pipeline is squeezed and covered to reduce the chance of biomacromolecules in contact with the inner wall.

The invention relates to a device for AIDS diagnosis in a dual-drive coupling mode with an easily disassembled structure, belonging to the field of analysis and testing. There are several obstacles in making the substrate of the microfluidic chip for AIDS diagnosis with cheap and easy-to-process polydimethylsiloxane (PDMS). The main point of this case is that the PDMS with the original ecological surface is selected for the substrate, and the elastic clamp with the micro-ultrasonic transducer attached to the clamping arm is positioned at the terminal position of the sample liquid flow of the chip by elastic bite. The driving force based on the difference in interfacial tension is formed, and at the same time, it is coupled with the driving force of the micropump to jointly drive the sample liquid to flow in the direction of the terminal. The pipe of the chip is filled with micron-sized silica particle fillers. The functions include supporting the inner wall of the pipeline, compensating the originally hydrophobic pipeline with a collection of hydrophilic micro-channels, and squeezing and covering the inner wall of the pipeline so as to reduce the chance of biomacromolecules contacting the inner wall.

The invention relates to a cholera-diagnosing apparatus with recyclable and easily-dismantlable driving members, belonging to the field of analytical testing. A series of obstacles exist in preparation of a substrate for a cholera-diagnosing micro-fluidic chip from cheap and easily workable polydimethylsiloxane (PDMS). According to main points of a technical scheme in the invention, PDMS with an original surface is selected as a substrate; an elastic clamp, additionally provided with a minisized ultrasonic transducer on its clamping arm, is positioned at a position where the sample liquid flowterminal of a micro-fluidic chip is located in the manner of elastic occlusion, and ultrasonic waves are used for inducing formation of a driving force based on the difference between interfacial tension forces; meanwhile, the driving force is coupled and coordinated with the driving force of a micropump to drive sample liquid flow to flow toward the terminal; and the pipelines of the chip are filled with a micronsized silica particle filler which is used for supporting the inner walls of the pipelines, compensating original hydrophobic pipelines with a set of hydrophilic micro-channels, andextruding and covering the inner wall surfaces of the pipelines so as to reduce the contact between biological macromolecules and the inner wall surfaces.

The invention relates to a microfluidic chip device for syphilis diagnosis with polydimethylsiloxane as a substrate, belonging to the field of analysis and testing. There are some difficulties in making the substrate of the microfluidic chip for syphilis diagnosis with cheap and easy-to-process polydimethylsiloxane (PDMS). The gist of this case is that the substrate is selected from PDMS with an original ecological surface, and the hinged fixture with a micro-ultrasonic transducer is manually fastened and positioned at the position adjacent to the sample liquid flow terminal of the microfluidic chip, so as to Ultrasound induces the driving force based on the difference in interfacial tension, and at the same time, it is coupled with the driving force of the micropump to drive the sample liquid to flow in the direction of the terminal. The pipe of the chip is filled with micron-sized silica particles. Its functions include supporting the inner wall of the pipeline, compensating the original hydrophobic pipeline with a collection of hydrophilic micro-channels, and squeezing and covering the inner wall of the pipeline so as to reduce the chance of biomacromolecules in contact with the inner wall.

The invention relates to a multi-channel chip device for AIDS diagnosis using PDMS as a substrate, belonging to the field of analysis and testing. Using cheap and easy-to-process polydimethylsiloxane (PDMS) to make the substrate of the microfluidic chip for AIDS diagnosis has a series of problems. The gist of this case is that the substrate is selected from PDMS with an original ecological surface, and the hinged fixture with a micro-ultrasonic transducer is manually fastened and positioned at the position adjacent to the sample liquid flow terminal of the microfluidic chip, so as to Ultrasound induces the driving force based on the difference in interfacial tension, and at the same time, it is coupled with the driving force of the micropump to drive the sample liquid to flow in the direction of the terminal. The pipe of the chip is filled with micron-sized silica particles. Its functions include supporting the inner wall of the pipeline, compensating the original hydrophobic pipeline with a collection of hydrophilic micro-channels, and squeezing and covering the inner wall of the pipeline so as to reduce the chance of biomacromolecules in contact with the inner wall.

The invention relates to a cholera-diagnosing micro-fluidic chip unit with PDMS as a substrate material, belonging to the field of analytical testing. A series of obstacles exist in preparation of a substrate for a cholera-diagnosing micro-fluidic chip from cheap and easily workable polydimethylsiloxane (PDMS). According to main points of a technical scheme in the invention, PDMS with an originalsurface is selected as a substrate; a hinge-type clamp, additionally provided with a minisized ultrasonic transducer, is manually fastened and positioned at a position close to the sample liquid flowterminal of the micro-fluidic chip, and ultrasonic waves are used for inducing formation of a driving force based on the difference between interfacial tension forces; meanwhile, the driving force iscoupled and coordinated with the driving force of a micropump to drive sample liquid flow to flow toward the terminal; and the pipelines of the chip are filled with a micronsized silica particle filler which is used for supporting the inner walls of the pipelines, compensating original hydrophobic pipelines with a set of hydrophilic micro-channels, and extruding and covering the inner wall surfaces of the pipelines so as to reduce the contact between biological macromolecules and the inner wall surfaces.

The invention relates to a microfluidic chip device for subtype swine influenza detection comprising a hydrophobic substrate, which belongs to the field of analysis and testing. There are several difficulties in using cheap and easy-to-process polydimethylsiloxane (PDMS) to fabricate the substrate of the microfluidic chip for subtype swine influenza diagnosis. The main point of this case is that PDMS with an original ecological surface is selected as the substrate, and the hinge-type fixture with a micro-ultrasonic transducer is manually fastened and positioned at the terminal position of the sample liquid flow of the chip, and an interface-based surface is formed by ultrasonic induction. The driving force of the tension difference, coupled with the driving force of the micropump, synergistically drives the sample liquid to flow in the direction of the terminal. The pipe of the chip is filled with micron-sized silica particle fillers. The functions of the filler include supporting The inner wall of the pipeline, and the original hydrophobic pipeline is compensated by a collection of hydrophilic micro-channels, and the inner wall of the pipeline is squeezed and covered to reduce the chance of biomacromolecules in contact with the inner wall.

The present invention relates to a subtype swine influenza detection apparatus capable of being conveniently disassembled and using a dual-drive coupling mode, and belongs to the field of analytical testing. According to the present invention, the use of inexpensive and easily-processed polydimethylsiloxane (PDMS) to produce the substrate of a microfluidic chip for diagnosing subtype swine influenza has a plurality of problems. The technical scheme of the present invention is characterized in that the substrate selects PDMS having an original ecological surface, an elastic clamper provided with a micro-ultrasonic wave transducer arranged on the clamping arm is positioned on the sample liquid flow terminal position of the microfluidic chip in an elastic snapping manner, ultrasonic waves induce to form driving force based on the interfacial tension difference, and through the coupled operation with the driving force of a micro pump, the sample liquid flow is synergistically driven to flow to the terminal direction; and the pipeline of the chip is filled with a micro-scale silica particle filler, and the micro-scale silica particle filler is used for supporting the inner wall of the pipeline, compensating the original hydrophobic pipeline with a hydrophilic micro-channel set, and extruding and covering the inner wall surface of the pipeline so as to reduce the opportunity of the contact between biological macromolecules and the inner wall surface.

The present invention relates to an easy-to-disassembly structure AIDS diagnostic device using a dual-drive coupled mode, and belongs to the field of analysis and testing. When inexpensive and highlyprocessable polydimethylsiloxane, namely PDMS is used for making a substrate of a microfluidic chip for diagnosis of AIDS, a plurality of obstacles are needed to be solved. The main point of the microfluidic chip device is that the material of the substrate is the PDMS with an original ecological surface, and the pipe of the chip is filled with doped micron-sized titanium dioxide particles; the titanium dioxide particles have super-hydrophilic surface induced in advance by visible light irradiation; collection of super-hydrophilic channels among the particles of a titanium dioxide particle filler compensates and surpasses an original strong hydrophobic pipe, a constant and super-hydrophilic modification effect can be achieved, and by a small-power ultrasonic drive and micro-pump drive dual-drive coupled operation mode, a sample flow is guided to flow along the pipe of the chip to terminal direction.

The invention relates to an easily-dismantlable dual-drive-coupled detection apparatus for swine influenza subtypes, belonging to the field of analytical testing. A series of obstacles practically exist in preparation of a substrate for a swine influenza subtype diagnosis micro-fluidic chip from cheap and easily workable polydimethylsiloxane (PDMS). According to main points of a technical scheme in the invention, PDMS with an original surface is selected as a substrate; an elastic clamp, additionally provided with a minisized ultrasonic transducer on its clamping arm, is positioned at a position where a sample liquid flow terminal of a micro-fluidic chip is located in the manner of elastic occlusion, and ultrasonic waves are used for inducing formation of a driving force based on the difference between interfacial tension forces; meanwhile, the driving force is coupled and coordinated with the driving force of a micropump to drive sample liquid flow to flow toward the terminal; and thepipelines of the chip are filled with a micronsized silica particle filler which is used for supporting the inner walls of the pipelines, compensating original hydrophobic pipelines with a set of hydrophilic micro-channels, and extruding and covering the inner wall surfaces of the pipelines so as to reduce the contact between biological macromolecules and the inner wall surfaces.

The invention relates to a multichannel microfluidic chip device relating to a hydrophobic substrate and used for diagnosis of AIDS, belonging to the field of analytical testing. According to the invention, a plurality of problems are generated in manufacturing of a substrate of a microfluidic chip used for diagnosis of AIDS from cheap and easily-processed polydimethylsiloxane, i.e., PDMS. The main points of a technical scheme of the invention are as follows: the material of the substrate is PDMS with a nascent surface; the interiors of the channels of a chip are filled with doped micron-sizedtitanium dioxide particles, wherein the super-hydrophilic properties of the surface of the titanium dioxide particles can be induced out through preset visible-light irradiation; an assembly of gapsand channels among particles of the titanium dioxide particle filling material compensates and surpasses original highly-hydrophobic channels, so constant and super-hydrophilic modification effects are achieved; meanwhile, through a manner of coupling operation combining micropower ultrasonic-wave driving and micropump driving, a test specimen liquid flow is guided to flow towards the terminal direction along the channels of the chip.

The invention relates to a microfluidic chip device used for diagnosis of syphilis and using polydimethylsiloxane as a substrate, belonging to the field of analytical testing. According to the invention, a plurality of problems are generated in manufacturing of a substrate of a microfluidic chip used for diagnosis of syphilis from cheap and easily-processed polydimethylsiloxane, i.e., PDMS. The main points of a technical scheme of the invention are as follows: the material of the substrate is PDMS with a nascent surface; the interiors of the channels of a chip are filled with doped micron-sized titanium dioxide particles, wherein the super-hydrophilic properties of the surface of the titanium dioxide particles can be induced out through preset visible-light irradiation; an assembly of gapsand channels among particles of the titanium dioxide particle filling material compensates and surpasses original highly-hydrophobic channels, so constant and super-hydrophilic modification effects are achieved; meanwhile, through a manner of coupling operation combining micropower ultrasonic-wave driving and micropump driving, a test specimen liquid flow is guided to flow towards the terminal direction along the channels of the chip.

The invention relates to a device for AIDS diagnosis in a dual-drive coupling mode with an easily disassembled structure, belonging to the field of analysis and testing. There are several obstacles in making the substrate of the microfluidic chip for AIDS diagnosis with cheap and easy-to-process polydimethylsiloxane (PDMS). The main point of this case is that the PDMS with the original ecological surface is selected for the substrate, and the elastic clip with the micro-ultrasonic transducer attached to the clamping arm is positioned at the terminal position of the sample liquid flow of the chip by elastic snapping. The driving force based on the difference in interfacial tension is formed, and at the same time, it is coupled with the driving force of the micropump to jointly drive the sample liquid to flow in the direction of the terminal. The pipeline of the chip is filled with micron-sized silica particle fillers. The functions include supporting the inner wall of the pipeline, compensating the originally hydrophobic pipeline with a collection of hydrophilic micro-channels, and squeezing and covering the inner wall of the pipeline so as to reduce the chance of biomacromolecules contacting the inner wall.

The invention relates to a multi-channel microfluidic chip device for AIDS diagnosis involving a hydrophobic substrate, belonging to the field of analysis and testing. There are several difficulties in making the substrate of the microfluidic chip for AIDS diagnosis with cheap and easy-to-process polydimethylsiloxane (PDMS). The main point of this case is that PDMS with an original ecological surface is selected as the substrate, and the hinged fixture with a micro-ultrasonic transducer is manually fastened and positioned at the terminal position of the sample liquid flow of the microfluidic chip. The driving force based on the difference in interfacial tension is formed, and at the same time, it is coupled with the driving force of the micropump to jointly drive the sample liquid to flow in the direction of the terminal. The pipe of the chip is filled with micron-sized silica particle fillers. The functions include supporting the inner wall of the pipeline, compensating the originally hydrophobic pipeline with a collection of hydrophilic micro-channels, and squeezing and covering the inner wall of the pipeline so as to reduce the chance of biomacromolecules contacting the inner wall.

The invention relates to a microfluidic chip device for subtype swine influenza detection containing a hydrophobic substrate, and belongs to the field of analysis and testing. Cheap and easy-to-process polydimethylsiloxane, i.e. PDMS, is used for preparing the substrate of a microfluidic chip for subtype swine influenza diagnosis, which has a plurality of challenges. The key points of the invention are as follows: the material of the substrate is the PDMS with an original form surface; a pipeline of the chip is filled with doped micron-sized silicon dioxide particles; the silicon dioxide particles are ones which can have surface super-hydrophilic nature under the induction of previous visible light radiation; a collection of inter-particle super-hydrophilic gaps of the titanium dioxide particle fillers compensates for and overrides the original highly hydrophobic pipeline, thereby achieving a constant and super-hydrophilic modification effect; and meanwhile, a sample liquid flow is guided to flow towards a terminal along the pipeline of the chip in a micro-power ultrasonic drive and micropump drive coupled operation manner.

The invention relates to a microfluidic chip device for subtype swine influenza detection using a strong hydrophobic substrate, belonging to the field of analysis and testing. There are actually a series of difficulties in using cheap and easy-to-process polydimethylsiloxane (PDMS) to fabricate the substrate of the microfluidic chip for subtype swine influenza diagnosis. The main point of this case is that the PDMS with the original ecological surface is selected as the substrate, and the hinged fixture with the micro-ultrasonic transducer is manually fastened and positioned at the terminal position of the sample liquid flow of the chip, and the interface is formed by ultrasonic induction. The driving force of the tension difference, coupled with the driving force of the micropump, synergistically drives the sample liquid to flow in the direction of the terminal. The pipe of the chip is filled with micron-sized silica particle fillers. The functions of the filler include supporting The inner wall of the pipeline, and a collection of hydrophilic micro-channels are used to compensate the original hydrophobic pipeline, and the inner wall of the pipeline is squeezed and covered to reduce the chance of biomacromolecules in contact with the inner wall.

The invention relates to a fifteen-channel microfluidic chip device for screening common tumor markers, belonging to the field of analysis and testing. If PDMS, or polydimethylsiloxane, is used to make the substrate of a microfluidic chip for the joint detection of more than ten tumor markers, there are some difficulties. The main point of this case is that the PDMS with the original ecological surface is selected for the substrate, and the elastic clip with the micro-ultrasonic transducer attached to the clamping arm is positioned at the terminal position of the sample liquid flow of the chip by elastic snapping. The driving force based on the difference in interfacial tension is formed, and at the same time, it is coupled with the driving force of the micropump to drive the sample liquid to flow in the direction of the terminal. The pipe of the chip is filled with micron-sized silica particle fillers. It includes supporting the inner wall of the pipeline, and compensating the original hydrophobic pipeline with a collection of hydrophilic micro-channels, and squeezing and covering the inner wall of the pipeline so as to reduce the chance of biomacromolecules contacting the inner wall.

The invention relates to a chip device for joint detection of male typical tumor markers coupled with double drives, belonging to the field of analysis and testing. Polydimethylsiloxane, or PDMS, is used to make the substrate of a microfluidic chip for the joint detection of seven typical tumor markers in men, and there are a series of problems. The main point of this case is that the PDMS with the original ecological surface is selected for the substrate, and the elastic clip with the micro-ultrasonic transducer attached to the clamping arm is positioned at the terminal position of the sample liquid flow of the chip by elastic snapping. The driving force based on the difference in interfacial tension is formed, and at the same time, it is coupled with the driving force of the micropump to jointly drive the sample liquid to flow in the direction of the terminal. The pipeline of the chip is filled with micron-sized silica particle fillers. The functions include supporting the inner wall of the pipeline, compensating the originally hydrophobic pipeline with a collection of hydrophilic micro-channels, and squeezing and covering the inner wall of the pipeline so as to reduce the chance of biomacromolecules contacting the inner wall.

The present invention relates to an easy-to-disassembly cholera diagnostic micro fluidic device using a dual-drive coupled mode, and belongs to the field of analysis and testing. When inexpensive andhighly processable polydimethylsiloxane, namely PDMS is used for making a substrate of a microfluidic chip for diagnosis of cholera, a series of problems are needed to be solved. The main point of thecholera diagnosis microfluidic device is that the material of the substrate is the PDMS with an original ecological surface, and the pipe of the chip is filled with doped micron-sized titanium dioxide particles; the titanium dioxide particles have super-hydrophilic surface induced in advance by visible light irradiation; collection of super-hydrophilic channels among the particles of a titanium dioxide particle filler compensates and surpasses an original strong hydrophobic pipe, a constant and super-hydrophilic modification effect can be achieved, and by a small-power ultrasonic drive and micro-pump drive dual-drive coupled operation mode, a sample flow is guided to flow along the pipe of the chip to terminal direction.

The present invention relates to a subtype swine influenza detection device using a fast-to-disassembly dual-drive coupled mode, and belongs to the field of analysis and testing. When inexpensive andhighly processable polydimethylsiloxane, namely PDMS is used for making a substrate of a microfluidic chip for diagnosis of subtype swine influenza, a series of problems are needed to be solved. The main point of the subtype swine influenza diagnosis microfluidic device is that the material of the substrate is the PDMS with an original ecological surface, and the pipe of the chip is filled with doped micron-sized titanium dioxide particles; the titanium dioxide particles have super-hydrophilic surface induced in advance by visible light irradiation; collection of super-hydrophilic channels among the particles of a titanium dioxide particle filler compensates and surpasses an original strong hydrophobic pipe, a constant and super-hydrophilic modification effect can be achieved, and by a small-power ultrasonic drive and micro-pump drive dual-drive coupled operation mode, a sample flow is guided to flow along the pipe of the chip to terminal direction.

The invention relates to a chip device for combined detection of six main tumor markers with a specific driving mode, which belongs to the field of analysis and testing. Polydimethylsiloxane, or PDMS, is used to make the substrate of a microfluidic chip for multi-channel joint detection of typical tumor markers, and there are difficulties. The main point of this case is that the PDMS with the original ecological surface is selected for the substrate, and the elastic clip with the micro-ultrasonic transducer attached to the clamping arm is positioned at the terminal position of the sample liquid flow of the chip by elastic snapping. The driving force based on the difference in interfacial tension is formed, and at the same time, it is coupled with the driving force of the micropump to jointly drive the sample liquid to flow in the direction of the terminal. The pipeline of the chip is filled with micron-sized silica particle fillers. The functions include supporting the inner wall of the pipeline, compensating the originally hydrophobic pipeline with a collection of hydrophilic micro-channels, and squeezing and covering the inner wall of the pipeline so as to reduce the chance of biomacromolecules contacting the inner wall.

The present invention relates to a microfluidic chip apparatus used for diagnosing cholera and selecting PDMS as a substrate material, and belongs to the field of analysis and testing. According to the present invention, the use of inexpensive and easily-processed polydimethylsiloxane (PDMS) to produce the substrate of a microfluidic chip for diagnosing cholera has the following series of problems; and the multichannel chip apparatus is characterized in that the substrate selects the PDMS having an original ecological surface, a hinge type fixture provided with a miniature ultrasonic wave transducer is manually fastened and positioned at a position close to the sample liquid flow terminal end of the microfluidic chip, ultrasonic waves induce to form the driving force based on interfacial tension difference, the ultrasonic wave induced driving force and the driving force of a micro pump are subjected to coupled operation so as to synergistically drive the sample liquid flow to flow to the terminal direction, the pipeline of the chip is filled with a micro-scale silica particle filler, and the micro-scale silica particle filler is used for supporting the inner wall of the pipeline, compensating the original hydrophobic pipeline with the set of hydrophilic micro-flow channels, and extruding and covering the inner wall surface of the pipeline so as to reduce the opportunity of thecontact between biological macromolecules and the inner wall surface.

The invention relates to an integrated chip device for combined detection of typical female tumor markers, which belongs to the field of analysis and testing. There are several difficulties in making the substrate of the microfluidic chip for joint detection of eight typical tumor markers suitable for women with PDMS, that is, polydimethylsiloxane. The main point of this case is that the PDMS with the original ecological surface is selected for the substrate, and the elastic clip with the micro-ultrasonic transducer attached to the clamping arm is positioned at the terminal position of the sample liquid flow of the chip by elastic snapping. The driving force based on the difference in interfacial tension is formed, and at the same time, it is coupled with the driving force of the micropump to jointly drive the sample liquid to flow in the direction of the terminal. The pipeline of the chip is filled with micron-sized silica particle fillers. The functions include supporting the inner wall of the pipeline, compensating the originally hydrophobic pipeline with a collection of hydrophilic micro-channels, and squeezing and covering the inner wall of the pipeline so as to reduce the chance of biomacromolecules contacting the inner wall.

The invention relates to a microfluidic chip device for multi-channel syphilis diagnosis, which belongs to the field of analysis and testing. There are some difficulties to be solved in making the substrate of the microfluidic chip for syphilis diagnosis with cheap and easy-to-process polydimethylsiloxane (PDMS). The gist of this case is that the substrate is selected from PDMS with an original ecological surface, and the hinged fixture with a micro-ultrasonic transducer is manually fastened and positioned at the position adjacent to the sample liquid flow terminal of the microfluidic chip, so as to Ultrasound induces the driving force based on the difference in interfacial tension, and at the same time, it is coupled with the driving force of the micropump to drive the sample liquid to flow in the direction of the terminal. The pipe of the chip is filled with micron-sized silica particles. Its functions include supporting the inner wall of the pipeline, compensating the original hydrophobic pipeline with a collection of hydrophilic micro-channels, and squeezing and covering the inner wall of the pipeline so as to reduce the chance of biomacromolecules in contact with the inner wall.

The invention relates to a multichannel microfluidic device used for diagnosis of cholera and containing a highly-hydrophobic chip substrate, belonging to the field of analytical testing. According tothe invention, a series of problems are generated in manufacturing of a substrate of a microfluidic chip used for diagnosis of cholera from cheap and easily-processed polydimethylsiloxane, i.e., PDMS. The main points of a technical scheme of the invention are as follows: the material of the substrate is PDMS with a nascent surface; the interiors of the channels of a chip are filled with doped micron-sized titanium dioxide particles, wherein the super-hydrophilic properties of the surface of the titanium dioxide particles can be induced out through preset visible-light irradiation; an assemblyof gaps and channels among particles of the titanium dioxide particle filling material compensates and surpasses original highly-hydrophobic channels, so constant and super-hydrophilic modification effects are achieved; meanwhile, through a manner of coupling operation combining micropower ultrasonic-wave driving and micropump driving, a test specimen liquid flow is guided to flow towards the terminal direction along the channels of the chip.