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Yinhuang (honeysuckle and Rdix astragali) soft capsule pharmaceutics and preparation process thereof

A technology of soft capsules and silver yellow, applied in the field of medicine, can solve the problems of slow disintegration and absorption, unstable quality, and unguaranteed safety, and achieve high bioavailability

Inactive Publication Date: 2008-02-13
山东希尔康泰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Yinhuang Injection is inconvenient for patients to administer. At the same time, the main components of the preparation, chlorogenic acid and baicalin, will be oxidized and degraded if placed in solution for a long time. The unstable quality will affect the curative effect, and the safety cannot be guaranteed.
Although the tablet has a simple process and low cost, its slow disintegration and absorption will affect the curative effect; the oral liquid is inconvenient to carry and transport, and the granules are inconvenient to take medicine
In addition, the volatile oil components of honeysuckle also have the effect of clearing heat and detoxifying, and all the oral preparations of Yinhuang did not retain the volatile oil components of honeysuckle during the preparation process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Component Quantity (g / granule)

[0024] Honeysuckle Extract 0.06

[0025] Baicalin 0.12

[0026] Corresponding amount of honeysuckle volatile oil

[0027] Polyethylene glycol 0.41

[0028] Glycerin 0.035

[0029] Appropriate amount of water

[0030] Capsule shell 0.20

Embodiment 2

[0032] Component Quantity (g / granule)

[0033] Honeysuckle Extract 0.04

[0034] Baicalin 0.08

[0035] Corresponding amount of honeysuckle volatile oil

[0036] Isopropanol 0.25

[0037] Ethoxylated hydrogenated castor oil 0.03

[0038] Glycerin 0.02

[0039] Appropriate amount of water

[0040] Capsule shell 0.17

Embodiment 3

[0042] Component Weight (g / granule)

[0043] Honeysuckle Extract 0.08

[0044] Baicalin 0.16

[0045] Corresponding amount of honeysuckle volatile oil

[0046] Corn oil 0.60

[0047] Soy lecithin 0.02

[0048] Beeswax 0.04

[0049] Appropriate amount of water

[0050] Capsule shell 0.19

[0051] The preparation process of embodiment is as follows:

[0052] Honeysuckle extracts the volatile oil in it by steam distillation or carbon dioxide supercritical extraction, collects the volatile oil and honeysuckle dregs, and extracts the dregs according to the law to obtain the honeysuckle extract. Add water to decoct the dregs for two times, the first time for 1 hour, and the second time for 45 minutes to filter, the filtrate is combined and concentrated under reduced pressure to 2g of honeysuckle per ml, add 20% lime milk, adjust the pH to 12-13 and stir well , stand still, filter, discard the filtrate, add 2 times the amount of ethanol to the precipitate, stir well, pass thr...

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PUM

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Abstract

The present invention relates to a yinhuang soft capsule oral medicine preparation and its preparation method. The liquid medicine contains extract of lonicera flower, baicalin, flonicera flower volatile oil, solvent and stabilizing agent. The mixing ratio of gelating and glycerine is 10:3.15-3.35 (weight ratio) in the capsule shell, and the preservative also is contained. When it is prepared, firstly, the lonicera flower volatile oil is extracted, then the press process if adopted so as to obtain the invented soft capsule. As compared with existent dosage form of yinhuang said invention has the advantages of stable quality, convenient for carryover and administration and quick dissolution of effective component.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a Yinhuang soft capsule preparation for treating upper respiratory tract infection, acute tonsillitis, pharyngitis and other diseases and a preparation method thereof. Background technique [0002] Yinhuang has the effects of clearing away heat, detoxifying, and soothing the throat. It is used for acute tonsillitis, upper respiratory tract infection, and wind-heat invading the lungs resulting in fever, cough, and sore throat. Yinhuang needles, tablets, granules and oral liquids made from honeysuckle and Scutellaria baicalensis extracts have all come out. Yinhuang Injection is inconvenient for patients to administer. At the same time, the main components of the preparation, chlorogenic acid and baicalin, will be oxidized and degraded if left in solution for a long time. Although the tablet is simple in process and low in cost, its slow disintegration and absorption a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K36/35A61K36/539A61K9/48A61P11/00A61P11/04A61P11/14A61P31/00
Inventor 张卫东苏娟周耘杨杰张川
Owner 山东希尔康泰药业有限公司