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Bufonin preparation for cancer treating

A technology of cinobufacin and preparations, applied in the field of medicine

Inactive Publication Date: 2008-02-27
叶耀良
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The above-mentioned preparations are all injections. With the advancement of preparation technology and the needs of cancer treatment, it is possible to make the above-mentioned active ingredients into oral compound preparations with high bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach ： Embodiment 1

[0076] Specific embodiments: Example 1: Extraction of a cinobufacin preparation for treating cancer:

[0077] Take dry toad skin, wash it, add 4 times the amount of water and decoct 3 times, the first 45 hours, the second and third 30 minutes, combine the decoction, filter, concentrate the filtrate to a relative density of 1.0 (50 ℃), cool To 30°C, add ethanol to make the alcohol content reach 50%, stir well, let it stand at 10°C for 12 hours, take the supernatant to recover the ethanol until it has no alcohol smell, add ethanol to make the alcohol content reach 65%, stir well, 10°C Let it stand for 24 hours, filter, recover the ethanol until it has no alcohol smell, and concentrate it into a thick paste with a relative density of 1.10 (60°C), which is the dry toad skin extract.

Embodiment 2

[0078] Example 2: Extraction of a cinobufacin preparation for treating cancer:

[0079] Take dry toad skin, wash it, add 6 times the amount of water and decoct twice, the first time is 45 hours, the second time is 30 minutes, combine the decoction, filter, the filtrate is concentrated to a relative density of 1.15 (80°C), and cooled to 40°C, add ethanol to make the alcohol content reach 60%, stir well, let it stand at 5°C for 24 hours, take the supernatant to recover the ethanol until it has no alcohol smell, add ethanol to make the alcohol content reach 85%, stir well, 5 Stand at ℃ for 48 hours, filter, recover ethanol until it has no alcohol smell, and concentrate it into a thick paste with a relative density of 1.20 (60 ℃), which is the dry toad skin extract.

Embodiment 3

[0080] Example 3: Extraction of a cinobufacin preparation for treating cancer:

[0081] Take dry toad skin, wash it, add 8 times the amount of water and decoct once for 1 hour, combine the decoction, filter, concentrate the filtrate to a relative density of 1.4 (80°C), cool to 50°C, add ethanol to make the alcohol When the alcohol content reaches 85%, stir well, let it stand for 48 hours, take the supernatant to recover ethanol until it has no alcohol smell, add ethanol to make the alcohol content reach 85%, stir well, let stand at 5°C for 72 hours, filter, and recover ethanol to It has no alcohol smell and is concentrated into a thick paste with a relative density of 1.3 (60°C), which is to prepare dry toad skin extract.

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PUM

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Abstract

The invention provides a medicinal composition of Cinobufacini, which is prepared into the forms of drop pill, or dispersible tablet, or soft capsule, or effervescent tablet, or orally disintegrating tablet, or mini-pill, or suppository. The invention also discloses their preparing process. The composition comprises dried toad skin extract and Job's-tears seed oily extract by the weight ratio of 1:0.05-30.

Description

Technical field: [0001] The invention relates to the field of medicine, in particular to a preparation method of a cinobufacin preparation for treating cancer. Background technique: [0002] Dried toad, or dried toad skin is the dried whole body of Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider, which are Bufo bufo bufo gargarizans Cantor. Most of them are caught and killed in summer and autumn, the internal organs are removed, washed and dried in the sun. When in use, brush off dust and dirt, cut off the head and claws, and cut into cubes. [0003] The medicinal material standards are included in the first volume of Chinese medicinal materials in drug standards of the Ministry of Health of the People's Republic of China. [0004] The medicinal material is pungent, cool and poisonous. Return liver, spleen, lung meridian. It has the functions of breaking knots, eliminating malnutrition accumulation, running water, detoxification, killing parasites, and relie...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K35/56A61P35/00A61K35/65
Inventor 叶耀良廖志钟
Owner 叶耀良
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