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Abedol slow release tablet and its preparation method

A technology of Arbidol and sustained-release tablets, which is applied in the field of antiviral drug Arbidol hydrochloride sustained-release tablets, which can solve the problems of inconvenient medication and short half-life of patients

Inactive Publication Date: 2008-07-16
CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the short half-life of Arbidol, in order to achieve the best therapeutic effect, ordinary Arbidol tablets or capsules need to be administered 3 to 4 times a day, 200 mg each time, during clinical medication, which brings great benefits to patients. inconvenient

Method used

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  • Abedol slow release tablet and its preparation method
  • Abedol slow release tablet and its preparation method
  • Abedol slow release tablet and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1: Arbidol Hydrochloride Hydrophilic Gel Matrix Sustained Release Tablets

[0040] formula:

[0041]

[0042]

[0043] Preparation Process:

[0044] Grind Arbidol hydrochloride through a 80-mesh sieve, mix evenly with Methocel K4M and lactose, moisten with 10% polyvinylpyrrolidone + 2% tartaric acid 95% ethanol solution, then granulate, dry at 45-50°C, and granulate. Add magnesium stearate and talcum powder, mix evenly and press into tablets.

[0045] Release test:

[0046] In order to investigate the in vitro release characteristics of Arbidol Hydrochloride Sustained-release Tablets, the release of the samples was determined by the first method (basket method) of Appendix XC of Part Two of the Chinese Pharmacopoeia 2000 Edition. With 900ml of water as solvent, the rotating speed is 100 revolutions per minute, sampling respectively in 1, 2, 4, 6, and 8 hours, according to spectrophotometry (Chinese Pharmacopoeia 2000 edition two appendix IVA), measure t...

Embodiment 2

[0051] Embodiment 2: Arbidol Hydrochloride Hydrophilic Gel Matrix Sustained Release Tablets

[0052] formula:

[0053]

[0054] Preparation Process:

[0055] Grind Arbidol hydrochloride through an 80-mesh sieve, mix it with Methocel K15M and microcrystalline cellulose, wet it with 10% polyvinylpyrrolidone + 2% tartaric acid 95% ethanol solution, and granulate it, and dry it at 45-50°C Whole grains, add magnesium stearate and talcum powder, mix evenly and press into tablets.

Embodiment 3

[0056]Embodiment 3: Arbidol Hydrochloride Hydrophilic Gel Matrix Sustained Release Tablets

[0057]

[0058]

[0059] Preparation Process:

[0060] Arbidol hydrochloride was crushed through a 80-mesh sieve, mixed evenly with sodium alginate and microcrystalline cellulose, then wetted with 0.5% hydroxypropyl methylcellulose + 2% tartaric acid 60% ethanol solution, and then granulated, at 45 ~50□ After drying, granulate, add magnesium stearate and talcum powder, mix evenly and press into tablets.

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PUM

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Abstract

A slow-release tablet of Abiduoer as an antivirus medicine features that in order to make it be dissolved in water, it can contain the hydrophilic gel skeleton (hydroxypropylmethyl cellulose) or the wax skeleton (glyceride behenate). Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a slow-release tablet of antiviral drug Arbidol hydrochloride. Background technique [0002] Arbidol hydrochloride is a new antiviral drug. It has the most significant antiviral activity on influenza viruses with A and B antigens, and can selectively inhibit the replication of A and B influenza viruses in cell culture media. Arbidol also has immunoregulatory effects, can induce the production of interferon, activate macrophages, and improve the body's resistance to viral infections. It is a new type of drug used to treat influenza and acute respiratory viral infections caused by A and B viruses Antiviral drugs. [0003] Animal pharmacokinetic experiments showed that after intragastric administration of Arbidol (150mg / kg) in rats, the absorption was rapid, the plasma tmax was 20min, and the t1 / 2 was 6.7h. Due to the short half-life of Arbidol, in order to achieve the best therapeutic effect, ordinary Arbidol tablets or capsul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/405A61K9/22A61P31/16A61P31/12
Inventor 牛占旗刘立云申东民梁敏陈素锐
Owner CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD