Method for extracting breviscapine from fresh erigeron breviscapus
A technology of scutellarin and its extraction method, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve problems such as increased production costs, increased processes, and reduced scutellarin content, and achieves improved utilization efficiency , low cost and high controllability
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Embodiment 1
[0017] A method for extracting scutellarin from fresh scutellaria scutellaria, taking an appropriate amount of fresh scutellaria scutellaria harvested within 3 days without corruption, washing with water, drying the surface water, cutting into small pieces of 1cm to 2cm, adding With a volume fraction of 40%, methanol aqueous solution preheated to 50°C, the ratio of methanol aqueous solution to scutellaria scutellaria is 2L / kg, reflux extraction at 50°C for 5 times, each extraction for 1 hour; combine the extracts, recover the alcohol, Concentrate until the solution volume / raw material is 2L / kg, adjust the pH value to 6.0 with sodium hydroxide, let it stand for 0.5 hours, filter, heat the filtrate to 50°C, adjust the pH value to 0.5 with hydrochloric acid, keep it standing for 0.5 hours, filter, Collect the filter cake, wash with water, 40% methanol aqueous solution and 95% methanol aqueous solution, and dry to obtain the crude crystals of scutellarin; take the crude crystals of...
Embodiment 2
[0019] Take an appropriate amount of fresh scutellaria breviscapus that has not been corrupted after fresh-keeping treatment, wash it with clean water, dry off the surface water, cut it into small pieces of 5cm to 6cm, add 70% by volume methanol aqueous solution that has been preheated to 65°C, methanol The ratio of aqueous solution to scutellaria breviscapus is 6L / kg, reflux extraction at 65°C for 4 times, each time for 4 hours; combine the extracts, recover the alcohol, concentrate to a solution volume / raw material of 1L / kg, adjust with potassium hydroxide The pH value is 6.5, let it stand for 5 hours, filter, heat the filtrate to 65°C, adjust the pH value to 1.5 with sulfuric acid, keep it for 2.5 hours, filter, collect the filter cake, and use water, 60% methanol aqueous solution and 95% methanol aqueous solution respectively After washing and drying, crude crystals of scutellarin were obtained; the crude crystals of scutellarin were taken and added to methanol aqueous solu...
Embodiment 3
[0021] Take an appropriate amount of freshly harvested fresh scutellaria scutellaria, wash it with water, dry off the surface water, cut into small pieces of 9cm-10cm, add methanol that has been preheated to 80°C, the ratio of methanol to scutellaria scutellaria is 10L / kg, reflux extraction at 80°C for 2 times, each time for 7 hours; combine the extracts, recover the alcohol solution, concentrate until the solution volume / raw material is 0.2L / kg, adjust the pH value to 7.5 with sodium phosphate, and let stand After 25 hours, filter, heat the filtrate to 80°C, adjust the pH value to 2.5 with phosphoric acid, keep the temperature for 5 hours, filter, collect the filter cake, wash with water, 80% methanol aqueous solution and 95% methanol aqueous solution, and dry to obtain lamps Crude crystals of scutellarin: Take the crude crystals of scutellarin and add methanol aqueous solution with a volume fraction of 80%, the ratio of the aqueous methanol solution to the crude crystals of s...
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