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Catalyst and its use for synthesizing 4-nitro-3-methyl benzoic acid

A technology of methylbenzoic acid and catalyst, applied in the field of catalyst and its application in the reaction of synthesizing 4-nitro-3-methylbenzoic acid, can solve the problems of unrecoverable initiator, low product selectivity and low reaction efficiency and other problems, to achieve strong industrial application prospects, high catalytic activity, and high reaction efficiency

Inactive Publication Date: 2008-11-19
ZHENGZHOU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with the above-mentioned first type of chemical oxidation method, the second type of catalytic oxidation method is economical and environmentally friendly, but the reported catalytic oxidation method is only one example of the above-mentioned Japanese patent
This method requires the use of a large amount of initiator that cannot be recovered, and the reaction efficiency is low, and the product selectivity is low, which limits the use of this method

Method used

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  • Catalyst and its use for synthesizing 4-nitro-3-methyl benzoic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Preparation of composite transition metal oxide component Co by co-precipitation method 2 CeOx:

[0021] Take 5.8g Co(NO 3 ) 2 ·6H 2 O, 4.3g Ce(NO 3 )3·6H 2 O and 150ml of distilled water are stirred together, drop dilute NaOH solution at 60-80°C, and control the pH value of the whole process and the end point to be 7; after the drop is completed, stir for 1 hour; Once, dry at 120°C, bake at 550°C for 2 hours, grind and sieve, and take 80-200 mesh particles to obtain the composite metal oxide component Co 2 CeOx.

Embodiment 2

[0022] Embodiment 2: Co-precipitation method prepares catalyst other composite metal oxide components

[0023] Except for the precursor, composition and calcination temperature of each metal oxide component, the preparation of other composite metal oxide components of the catalyst is the same as in Example 1, and the composite metal oxide components and compositions are shown in Table 1.

[0024] Table 1 Catalyst other composite metal oxide components and composition

[0025]

Embodiment 3

[0026] Example 3: Preparation of Catalyst Composite Metal Oxide Components by Grinding Method

[0027] Mix the directly purchased chemical products or single-component metal oxides of natural ore powder in a certain proportion, put them into a ball mill and grind them for 2-3 hours, sieve, and take 80-200 mesh particles to obtain the catalyst composite metal oxide group Point M 1 o x M 2 o y (m:n); M in the molecular formula 1 o x and M 2 o y Represents different metal oxides, m:n represents the molar ratio of the two, and the specific composition used is shown in the following examples.

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Abstract

The present invention relates to a catalyst, consisting of transition metal oxide and N-containing organic compound. The above-mentioned catalyst can be used in the reaction for synthesizing 4-nitro-3-methyl benzoic acid. Said invention uses a compound formed fron transition metal oxide and N-containing organic compound as catalyst and makes 2,4-dimethyl nitrobenzene and oxygen gas produce reaction for 0.5-20hr. under the condition of that air pressure is 0.01-2.00 MPa and temperature is 50-160deg.C so as to synthesize 4-nitro-3-methyl benzoic acid.

Description

technical field [0001] The invention relates to a catalyst and its application in the synthesis of 4-nitro-3-methylbenzoic acid. Background technique [0002] 4-Nitro-3-methylbenzoic acid is an important intermediate in organic synthesis and has a wide range of uses in organic synthesis, drug synthesis and pesticide synthesis. For example, 4-nitro-3-methylbenzoic acid is the starting material for the synthesis of the angiotensin II receptor antagonist telmisartan. [0003] Since 2,4-dimethylnitrobenzene is easy to produce and commercially available, 4-nitro-3-methylbenzoic acid is basically prepared by selective oxidation of 2,4-dimethylnitrobenzene. There are two main methods: (1) chemical oxidation of 2,4-dimethylnitrobenzene, and (2) catalytic oxidation of 2,4-dimethylnitrobenzene. Among them, 2,4-dimethylnitrobenzene chemical oxidation synthesis of 4-nitro-3-methylbenzoic acid is the most reported method, and the oxidants used in this method include: CrO in acetic acid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J31/02B01J23/85B01J23/889B01J23/83C07C205/57C07C201/12
Inventor 杨贯羽栾建新鲍改玲
Owner ZHENGZHOU UNIV