Simulated moving bed chromatographic focusing

A chromatographic column and injection tube technology, which is applied in the field of invention of different individual components in their respective regions, can solve problems such as low concentration of fractions and improve the problem, and achieve the effects of increasing product yield and purity, increasing yield, and reducing production consumption
CN100444920CInactive Publication Date: 2008-12-24ODEKO INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ODEKO INC
Publication Date
2008-12-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

A continuous simulated moving bed focusing chromatography method disclosing the separation and concentration of multiple components from a complex compound. This method consists of several zones connected together in a certain order, and the eluent is eluted unidirectionally along these zones, and is serially diluted one zone after another to reduce its desorption strength; each zone is equipped with A detachable column that periodically resets upstream one zone. The sample containing multiple components is injected into the downstream zone and adsorbed in the chromatography column in this zone, and is brought upstream zone by zone with the reset of the chromatography column, and is selectively desorbed from different zones And be separated. A certain component desorbed from one zone is re-adsorbed in the chromatography column in the adjacent downstream zone, and is brought back to the previous zone as the chromatography column is reset. The sample is thus maintained between the preceding zone and its adjacent downstream zone, and is accumulated by successive loadings and repeated resetting of the column.
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Description

technical field

[0001] The invention relates to a method for continuous chromatography using a multi-zone simulated moving bed structure. Rather, it is an invention that focuses on separating and concentrating the different individual components of a mixture in their respective regions. Background technique

[0002] Chromatographic separation can be divided into two ways: batch chromatography and continuous chromatography. Most routine chromatography is performed in batch chromatography. Typically, batch chromatography separates samples in batches. The separation process of each batch consists of the same steps of sample loading, elution and fraction collection, and chromatographic column regeneration. The advantage of batch chromatography is that it can be used to separate complex compounds. However, in order to ensure a good separation effect, the sample loading should be less than 1% of the total column volume. This is one of the defects of the batch chromatography m...

Claims

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