Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition containing amoxicillin, ambroxol and beta lactamase inhibitor and uses thereof

A technology of β-lactamase and amoxicillin, which is applied in the field of medicine, can solve problems such as failure to provide amoxicillin, achieve the effects of solving drug resistance, enhancing antibacterial effect, and inhibiting activity

Inactive Publication Date: 2009-10-28
颜锵
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing amoxicillin / ambroxol products and technologies fail to provide a good means to solve or deal with the problem of amoxicillin resistance, so as to give full play to the role of amoxicillin / ambroxol in the treatment of respiratory diseases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition containing amoxicillin, ambroxol and beta lactamase inhibitor and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Amoxicillin+potassium clavulanate+ambroxol hydrochloride tablets, each containing 250 mg of amoxicillin, 125 mg of clavulanic acid and 15 mg of ambroxol hydrochloride, 1000 tablets were prepared in total.

[0019] Amoxicillin 250g

[0020] Potassium clavulanate 125g (calculated as clavulanic acid)

[0021] Ambroxol Hydrochloride 15g

[0022] Microcrystalline Cellulose 70g

[0023] Micronized silica gel 10g

[0024] Croscarmellose Sodium 6g

[0025] Magnesium Stearate 9g

[0026]

[0027] Made into 1000 pieces

[0028] Preparation method: Take the prescribed amount of amoxicillin powder, potassium clavulanate powder and ambroxol hydrochloride powder and mix evenly, dry each auxiliary material separately and pass through a 100-mesh sieve, and add various auxiliary materials to three components according to the method of increasing in equal amounts In the mixed powder, the powder is directly compressed...

Embodiment 2

[0029] Example 2 Amoxicillin + clavulanic acid + ambroxol tablets, each containing 250 mg of amoxicillin, 62.5 mg of clavulanic acid and 15 mg of ambroxol, and a total of 1000 tablets were prepared.

[0030] Amoxicillin 250g

[0031] Clavulanate 62.5g

[0032] Ambroxol 15g

[0033] Microcrystalline Cellulose 50g

[0034] Micronized silica gel 8g

[0035] Croscarmellose Sodium 4g

[0036] Magnesium Stearate 6g

[0037]

[0038] Made into 1000 pieces

[0039] Preparation method: Take the prescribed amount of amoxicillin powder, clavulanic acid powder and ambroxol powder and mix evenly, dry each auxiliary material separately and pass through a 100-mesh sieve, and put various auxiliary materials and three-component mixed powder on a dry extrusion granulator Dry pressing into granules, tableting and coating.

Embodiment 3

[0040] Example 3 Amoxicillin sodium + potassium clavulanate + ambroxol hydrochloride capsules, each containing 250 mg of amoxicillin, 125 mg of clavulanic acid and 15 mg of ambroxol hydrochloride, 1000 capsules were prepared in total.

[0041] Amoxicillin sodium 250g (calculated as amoxicillin)

[0042] Potassium clavulanate 125g (calculated as clavulanic acid)

[0043] Ambroxol Hydrochloride 15g

[0044] Microcrystalline Cellulose 70g

[0045] Micronized silica gel 10g

[0046] Croscarmellose Sodium 6g

[0047] Magnesium Stearate 9g

[0048]

[0049] Make 1000 capsules

[0050] Preparation method: Take the prescribed amount of amoxicillin sodium powder, potassium clavulanate powder and ambroxol hydrochloride powder and mix evenly, dry each auxiliary material separately and pass through a 100-mesh sieve. Various auxiliary materials and three-component mixed powder are extruded Granules are dry-pressed on a granulator ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a pharmaceutical composition, which comprises amoxicillin or amoxicillin sodium salt, a β-lactamase inhibitor and ambroxol or ambroxol hydrochloride in an effective dose. The pharmaceutical composition of the present invention shows significant synergistic effect, can effectively inhibit the activity of β-lactamase, enhance the antibacterial activity of amoxicillin, solve the problem of drug resistance, increase the drug concentration of antibiotics in the respiratory tract, and enhance the antibacterial effect. It strengthens the results of treatment, improves curative effect, shortens the course of disease, and has the advantages of accurate dosage and convenient clinical application. The present invention is effective for respiratory diseases such as acute and chronic respiratory infections with abnormal secretion, especially acute bronchitis, asthmatic bronchitis, acute exacerbation of chronic bronchitis, bronchiectasis and bronchial asthma, as well as otitis media, pharyngitis, sinusitis, pneumonia and Tonsillitis has a good therapeutic effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing amoxicillin, ambroxol and a beta-lactamase inhibitor and its application in the preparation of medicines for treating respiratory diseases, otitis media or tonsillitis. Background technique [0002] Respiratory diseases such as acute bronchitis, asthmatic bronchitis, acute exacerbation of chronic bronchitis, bronchiectasis and bronchial asthma, as well as otitis media, pharyngitis, sinusitis, pneumonia and tonsillitis, are common multiple diseases. The morbidity and mortality are both on the rise. The common symptoms are cough, sputum, or accompanied by shortness of breath, wheezing, etc. In severe cases, emphysema and cor pulmonale may occur. Among them, cough, wheezing, phlegm, and inflammation symptoms often exist at the same time and are mutually causal. Clinically, expectorants and antibacterial drugs are often used in com...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/43A61K31/431A61K45/06A61P11/04A61P11/00A61P27/16A61K31/424
Inventor 周利娟陈亚军秦汉陵颜锵
Owner 颜锵
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com