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Pharmaceutical use of hesperidin and/or naringin

A technology of naringin and hesperidin, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, and drug combinations, and can solve the problem of less research on Chinese medicine monomers, limited effects, and no reports of hesperidin and naringin. Glycosides and other problems, to achieve good medicinal prospects, low toxicity, strong pharmacological effects

Active Publication Date: 2009-12-16
JIANGZI QINGFENG PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are already many chemical drugs that promote gastric motility, such as morphine, cisapride, erythromycin, etc., but their effects are limited, and their clinical application is limited due to problems such as high price and many side effects
[0003] There are many compound prescriptions of traditional Chinese medicine that have the effect of promoting gastric motility, such as Sini Powder, Banxia Xiexin Decoction, Renshen Decoction, Xiaojianzhong Decoction, etc., but there are few studies on the individual Chinese medicines
Hesperidin and naringin are flavonoids widely present in pomelo, citrus, orange, citrus aurantium, and citrus aurantium. They have been used as bittering agents, sweating agents, and have the effects of lowering cholesterol and treating acute and chronic bronchitis. However, there is no report on the application of hesperidin and naringin to promote gastric motility

Method used

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  • Pharmaceutical use of hesperidin and/or naringin
  • Pharmaceutical use of hesperidin and/or naringin
  • Pharmaceutical use of hesperidin and/or naringin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Citrus aurantium fine powder 600g, extract 3 times with 70% ethanol (crude drug: solvent weight ratio is 1:8; 1:6; 1:6), combine the extracts, recover ethanol until there is no alcohol smell, add distilled water to 600ml, water The solution was sequentially extracted with petroleum ether, ethyl acetate and n-butanol, 300ml each time. The n-butanol extraction part was concentrated and dried to obtain 82g, which was put on a D101 macroporous resin column, and eluted with water, 25% ethanol, 50% ethanol and 95% ethanol in sequence, and the 50% ethanol eluted part was concentrated and dried to obtain 20% The above mixed total glycosides of hesperidin and naringin (47g) were separated by silica gel column chromatography to obtain pure products of hesperidin (95%, 20g) and naringin (95%, 15g). The chemical structures of the above two pure products were confirmed by comparing with the IR, UV, NMR, m.p. and TLC of standard hesperidin and naringin.

Embodiment 2

[0040] Fully mix hesperidin (2g) and naringin (18g) at a ratio of 1:9, stir and grind to obtain a composition (20g) of hesperidin and naringin.

Embodiment 3

[0042] Fully mix hesperidin (10g) and naringin (10g) at a ratio of 1:1, stir and grind to obtain a composition (20g) of hesperidin and naringin.

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Abstract

The invention discloses the application of hesperidin and / or naringin in the preparation of drugs with the effect of promoting gastric motility. Use of hesperidin and / or naringin in the preparation of medicines for treating stomach distension, indigestion and anorexia in children.

Description

technical field [0001] The invention relates to the use of hesperidin and / or naringin in the preparation of drugs for promoting gastric motility. Background technique [0002] In recent years, human beings have made great progress in the understanding of gastric motility and its dysfunction. As one of the important physiological functions of the human stomach, motility has received more and more attention and research from the medical community. Insufficient gastric motility often leads to diseases such as bloating, indigestion or anorexia in children. There are already many chemical drugs that promote gastric motility, such as domperidone, cisapride, erythromycin, etc., but their effects are limited, and their clinical application is limited due to problems such as high price and many side effects. [0003] There are many compound prescriptions of traditional Chinese medicine that have the effect of promoting gastric motility, such as Sini Powder, Banxia Xiexin Decoction, ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P1/14
Inventor 叶文才王广基唐春山孙旭
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
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