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A technology for baicalein and baicalin, which is applied in the field of preparing baicalein, can solve the problems of high requirements on reaction conditions, troublesome refining process and high industrial cost, and achieves the effects of reducing production cost, low cost and short reaction time.
Inactive Publication Date: 2009-12-23
HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
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Problems solved by technology
Although this process can produce baicalein with higher purity, there are still problems such as deep color (many impurities), long reaction time, high requirements for reaction conditions, troublesome refining process, etc. of the product, which will cause poor quality and industrial cost too high
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Embodiment 1
[0020] Measure 80ml of water, pour it into a 500ml three-necked flask, stir, slowly add 110ml of 85% sulfuric acid, adjust the temperature to 70℃, add 20g of baicalin, dissolve, react for about 10 minutes, crystals precipitate, add about 300ml of water, and stir , Filter, wash with water 6 times to neutral, stir, and dry to obtain 12.0g sample.
Embodiment 2
[0022] Measure 80ml of water, pour it into a 500ml three-necked flask, stir, slowly add 110ml of 55% sulfuric acid, adjust the temperature to 60℃, add 20g of baicalin, dissolve, react for about 15 minutes, crystals precipitate, add about 100ml of water, and stir , Filter, wash with water 3 times to neutral, stir, and dry to obtain 11.5g of sample.
Embodiment 3
[0024] Measure 80ml of water, pour it into a 500ml three-necked flask, stir, slowly add 110ml of 70% sulfuric acid, adjust the temperature to 50℃, add 20g of baicalin, dissolve, react for about 12 minutes, crystals precipitate, add about 200ml of water, Stir, filter, wash 5 times with water to neutral, stir, and dry to obtain 11.8 g of sample.
[0025] 2. Crude product refinement
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Abstract
The invention discloses a method for preparing high-purity baicalein from baicalin. Add baicalin into sulfuric acid aqueous solution, react for 10-15 minutes at 50-70°C, crystals are precipitated to obtain a crude product, and then purified with acetone to obtain high-purity baicalein. Purity Baicalein. The obtained baicalein was determined by high performance liquid phase method, and the normalized method content was 96% or above. The method provided by the invention prepares finished products with high quality, high purity and light color, short reaction time, mild reaction conditions, simpler process and low cost. It is more suitable for industrial production.
Description
Technical field [0001] The invention belongs to a method for extracting traditional Chinese medicine, more specifically a method for preparing baicalein from baicalin. Background technique [0002] Scutellaria baicalensis is the dried root of Scutellaria baicalensis Georgi, a plant in the Lamiaceae family. It has the functions of clearing away heat and dampness, purging fire and detoxification, hemostasis and antifetus. Baicalein and Baicalin are the main components of Scutellaria baicalensis Georgi. They have exact chemical structures and their structural formulas are: [0003] [0004] Recent studies have found that these two Scutellaria baicalensis extracts have antibacterial and antiviral effects. In particular, baicalein is more effective in protecting liver and choleretic diuresis, scavenging free radicals and antioxidants, anti-coagulation and anti-thrombosis, and inhibiting pancreatin Pharmacological effects such as activity, effect on biofilm, anti-cancer, dual regulat...
Claims
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Application Information
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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/30
Inventor 潘福生叶杉
Owner HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
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