Compound orally disintegrating tablet of red sage root, its preparation method and detection method
A technology for oral disintegrating tablets and compound salvia, which is applied in the directions of measuring devices, pharmaceutical formulations, material testing products, etc., can solve the problem that the quality control method of compound danshen tablets is too simple, cannot comprehensively inspect and control product quality, and affect the clinical efficacy of drugs, etc. question
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Embodiment 2
[0212] Embodiment 2 of the present invention: described quality control method comprises the following contents:
[0213] Properties: The drug is light brown to light brown flakes with scattered spots on one side; the smell is fragrant and the taste is slightly bitter.
[0214] Identification: (1) Take 8 tablets of this preparation, grind them finely, add 15ml of ethanol and ethanol, ultrasonicate for 10 minutes, filter, and use the filtrate as the test solution; take borneol reference substance, add absolute ethanol to make each 1ml The solution containing 1 mg was used as the reference substance solution; according to the Chinese Pharmacopoeia Appendix VIB thin-layer chromatography test, draw 15 μl of the test solution and 5 μl of the reference substance solution, and place them on the same silica gel G thin-layer plate respectively, and use cyclohexane: acetic acid Ethyl ester=17:3 is the developer, develop, take out, dry in the air, spray with 1% vanillin sulfuric acid sol...
Embodiment 3
[0230] Embodiment 3 of the present invention: quality control method can comprise the following content:
[0231] Properties: The drug is light brown to light brown flakes with scattered spots on one side; the smell is fragrant and the taste is slightly bitter.
[0232] Identification: (1) Take 4 tablets of this preparation, grind them finely, put them in a centrifuge tube, add 9ml of dilute ammonia solution at about 40°C, shake to dissolve, centrifuge, take the supernatant, and pass through a column with an inner diameter of about 0.7ml and a column height of about 5ml of D101 type macroporous adsorption resin column, elute with 15ml of water, discard the water eluate, then elute with methanol, discard about 0.4ml of the initial eluent, collect about 5ml of the subsequent eluent, and use it as the test sample solution; another notoginseng saponin R 1 For the reference substance, add methanol to make a solution containing 2 mg per 1 ml, as the reference substance solution; ac...
Embodiment 4
[0240] Embodiment 4 of the present invention: quality control method can comprise the following content:
[0241] Properties: The drug is light brown to light brown flakes with scattered spots on one side; the smell is fragrant and the taste is slightly bitter.
[0242] Identification: (1) Take 8 tablets of this preparation, grind them finely, add 15ml of ethanol and ethanol, ultrasonicate for 10 minutes, filter, and use the filtrate as the test solution; take borneol reference substance, add absolute ethanol to make each 1ml The solution containing 1 mg was used as the reference substance solution; according to the Chinese Pharmacopoeia Appendix VIB thin-layer chromatography test, draw 15 μl of the test solution and 5 μl of the reference substance solution, and place them on the same silica gel G thin-layer plate respectively, and use cyclohexane: acetic acid Ethyl ester=17:3 is the developer, develop, take out, dry in the air, spray with 1% vanillin sulfuric acid solution, h...
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Abstract
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