Process for extracting carthamus tinctorius yellow pigment

A technology of safflower yellow pigment and an extraction method, which is applied in the field of extraction of effective components of safflower, can solve problems such as long extraction cycle, and achieve the effects of shortening production cycle, being beneficial to safe production and reducing loss.

Inactive Publication Date: 2007-08-01
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this method is that the extraction period is long and organic solvents are used

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0018] (1) Preparation of reference substance solution: take an appropriate amount of hydroxysafflor yellow A HSYA reference substance, add distilled water to make a solution containing 0.15mg in 1ml.

[0019] (2) Preparation of the test solution: take 15 mg of the sample, add water and dilute it to a 25 ml volumetric flask.

[0020] Accurately draw 20ul each of the above-mentioned reference substance solution and the test solution respectively, inject it into a liquid chromatograph, measure it, and obtain it.

Embodiment 1

[0021] Embodiment one safflower yellow pigment extraction process

[0022] Add 500g of safflower, add deionized water at 50°C and soak for 3 times, the amount of water added is 16 times, 10 times, 10 times of the weight of safflower, respectively, and the extraction time is 2 hours, 2 hours, 1 hour respectively. The three extracts were combined, adjusted to pH=2.0, and filtered. The filtrate was passed through macroporous resin D-4020, washed with water for 3 times the column volume, and discarded. The resin column continued to be eluted with water, and 6 times the column volume of water was collected. The eluate was concentrated through a reverse osmosis membrane to remove 80% of water, and the concentrate was dried under reduced pressure to obtain safflower yellow with a yield of 1.98% and a content of hydroxy safflower yellow of 32.0%.

Embodiment 2

[0023] Embodiment two safflower yellow pigment extraction process

[0024] For 500g of safflower, add deionized water and soak for 3 times at 60°C. The amount of water added is 16 times, 10 times, and 10 times of the weight of safflower, and the extraction time is 2 hours, 2 hours, and 1 hour respectively. The three extracts were combined, adjusted to pH=2.5, and filtered. The filtrate was passed through macroporous resin D-4020, washed with water for 3 times the column volume, and discarded. The resin column continued to be eluted with water, and 6 times the column volume of water was collected. The eluate was concentrated through a reverse osmosis membrane to remove 80% of water, and the concentrate was dried under reduced pressure to obtain safflower yellow with a yield of 1.87% and a content of hydroxy safflower yellow of 31.5%.

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Abstract

The invention provides a method for extracting carthamus tinctorius yellow colour, comprising following steps: 1) immersing safflower in warm water for 2- 4 times, mixing extracting liquid, filtering; 2) moderating pH of extracting liquid to 2.0- 4.0; 3) carrying out chromatography with non-polar macroreticular resin for extracting liquid, removing foreign matter through cleaning with water, eluting with water; 4) collecting eluting liquid, removing 70-90% water through hyperfiltration and consensation, vaccum consensing and drying left water solution and getting yellow powder, that is carthamus tinctorius yellow colour.

Description

technical field [0001] The invention relates to the field of extraction methods of herbal medicines, in particular to the field of extraction methods of active components of safflower. Background technique [0002] Safflower 〔Carthamus tinctorius L〕is the flower of the safflower plant of Compositae. It is an annual herb and is widely distributed in my country. Safflower promotes blood circulation and stimulates menstruation, removes blood stasis and relieves pain, and is used for various blood circulation disorders. Clinically, safflower is used as a decoction, and its main water-soluble component is safflor yellow (Safflor yellow, SY), and hydroxy safflor yellow (HSYA) is the chalcone component with the highest content. SY is a brown-yellow mixture of various water-active ingredients. It is one of the important ingredients in safflower with physiological activities. It has cardiovascular pharmacological activities such as anti-platelet activating factor. It is a water-solu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/08
Inventor 张兰兰林万里罗学军李德坤魏峰
Owner TIANJIN TASLY PHARMA CO LTD
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